methyl (methyl 3-deoxy-5,7,8-tri-O-methyl-α-D-manno-oct-2-ulopyranosid)onate 4-(diphenyl phosphate)

Base Information

Chemical Name:methyl (methyl 3-deoxy-5,7,8-tri-O-methyl-α-D-manno-oct-2-ulopyranosid)onate 4-(diphenyl phosphate)
CAS No.:133635-12-8
Molecular Formula:C₂₅H₃₃O₁₁P
Molecular Weight:540.504
Hs Code.:

Synonyms:methyl (methyl 3-deoxy-5,7,8-tri-O-methyl-α-D-manno-oct-2-ulopyranosid)onate 4-(diphenyl phosphate)

Suppliers and Price of methyl (methyl 3-deoxy-5,7,8-tri-O-methyl-α-D-manno-oct-2-ulopyranosid)onate 4-(diphenyl phosphate)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl (methyl 3-deoxy-5,7,8-tri-O-methyl-α-D-manno-oct-2-ulopyranosid)onate 4-(diphenyl phosphate)

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl (methyl 3-deoxy-5,7,8-tri-O-methyl-α-D-manno-oct-2-ulopyranosid)onate 4-(diphenyl phosphate)

There total 9 articles about methyl (methyl 3-deoxy-5,7,8-tri-O-methyl-α-D-manno-oct-2-ulopyranosid)onate 4-(diphenyl phosphate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 133635-11-7
methyl (methyl 3-deoxy-5,7,8-tri-O-methyl-α-D-manno-oct-2-ulopyranosid)onate

: 2524-64-3
chlorophosphoric acid diphenyl ester

: 133635-12-8
methyl (methyl 3-deoxy-5,7,8-tri-O-methyl-α-D-manno-oct-2-ulopyranosid)onate 4-(diphenyl phosphate)

Guidance literature:: With 1-methyl-1H-imidazole; In tetrahydrofuran; at 40 ℃; for 1h;

Reference yield:

: 111833-94-4
methyl 4-O-benzyl-3-deoxy-7,8-O-isopropylidene-α-D-manno-oct-2-ulopyrano-sidono-1,5-lactone

: 133635-12-8
methyl (methyl 3-deoxy-5,7,8-tri-O-methyl-α-D-manno-oct-2-ulopyranosid)onate 4-(diphenyl phosphate)

Guidance literature:: Multi-step reaction with 8 steps

1: methanol; CHCl₃ / 1 h

2: 91 percent / Ag₂O, CaSO₄ / 24 h / 35 °C / the methylation was repeated three times

3: 92 percent / H₂, 1percent methanolic NH₃ / 10percent Pd/C / ethyl acetate

4: 73 percent / pyridine, DMAP / 35 °C

5: 81 percent / aq. TFA, silica gel / CH₂Cl₂ / Ambient temperature

6: 80 percent / Ag₂O, CaSO₄ / 12 h / 35 °C / the same procedure was repeated

7: 57 mg / NaOCH₃ / methanol / Ambient temperature

8: 68 percent / N-methylimidazole / tetrahydrofuran / 1 h / 40 °C

With pyridine; 1-methyl-1H-imidazole; dmap; calcium sulfate; ammonia; hydrogen; sodium methylate; silica gel; trifluoroacetic acid; silver(l) oxide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; chloroform; ethyl acetate;

Reference yield:

: 114729-36-1
(2R,4R,5R,6S)-4-Benzyloxy-6-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-5-hydroxy-2-methoxy-tetrahydro-pyran-2-carboxylic acid methyl ester

: 133635-12-8
methyl (methyl 3-deoxy-5,7,8-tri-O-methyl-α-D-manno-oct-2-ulopyranosid)onate 4-(diphenyl phosphate)

Guidance literature:: Multi-step reaction with 7 steps

1: 91 percent / Ag₂O, CaSO₄ / 24 h / 35 °C / the methylation was repeated three times

2: 92 percent / H₂, 1percent methanolic NH₃ / 10percent Pd/C / ethyl acetate

3: 73 percent / pyridine, DMAP / 35 °C

4: 81 percent / aq. TFA, silica gel / CH₂Cl₂ / Ambient temperature

5: 80 percent / Ag₂O, CaSO₄ / 12 h / 35 °C / the same procedure was repeated

6: 57 mg / NaOCH₃ / methanol / Ambient temperature

7: 68 percent / N-methylimidazole / tetrahydrofuran / 1 h / 40 °C

With pyridine; 1-methyl-1H-imidazole; dmap; calcium sulfate; ammonia; hydrogen; sodium methylate; silica gel; trifluoroacetic acid; silver(l) oxide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate;