(4S,5R)-4-(benzyloxy)-5-{[(tert-butyl)(diphenyl)silyl]oxy}oct-7-en-1-ol

Base Information

Chemical Name:(4S,5R)-4-(benzyloxy)-5-{[(tert-butyl)(diphenyl)silyl]oxy}oct-7-en-1-ol
CAS No.:1401872-17-0
Molecular Formula:C₃₁H₄₀O₃Si
Molecular Weight:488.742
Hs Code.:

Synonyms:(4S,5R)-4-(benzyloxy)-5-{[(tert-butyl)(diphenyl)silyl]oxy}oct-7-en-1-ol

Suppliers and Price of (4S,5R)-4-(benzyloxy)-5-{[(tert-butyl)(diphenyl)silyl]oxy}oct-7-en-1-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4S,5R)-4-(benzyloxy)-5-{[(tert-butyl)(diphenyl)silyl]oxy}oct-7-en-1-ol

Chemical Property:

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Technology Process of (4S,5R)-4-(benzyloxy)-5-{[(tert-butyl)(diphenyl)silyl]oxy}oct-7-en-1-ol

There total 6 articles about (4S,5R)-4-(benzyloxy)-5-{[(tert-butyl)(diphenyl)silyl]oxy}oct-7-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1401872-22-7
C₃₉H₄₈O₄Si

: 1401872-17-0
(4S,5R)-4-(benzyloxy)-5-{[(tert-butyl)(diphenyl)silyl]oxy}oct-7-en-1-ol

Guidance literature:: With water; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; at 0 - 20 ℃; for 0.333333h; Inert atmosphere;
DOI:10.1002/hlca.201200064

Reference yield:

: 1380510-77-9
C₁₉H₂₈O₄

: 1401872-17-0
(4S,5R)-4-(benzyloxy)-5-{[(tert-butyl)(diphenyl)silyl]oxy}oct-7-en-1-ol

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

1.2: 6 h / 20 °C / Inert atmosphere

2.1: acetic acid / water / 12 h / 20 °C

3.1: triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

3.2: 4 h / 20 °C / Inert atmosphere

4.1: potassium carbonate / methanol / 1 h / 20 °C / Inert atmosphere

5.1: copper(l) iodide / tetrahydrofuran / 0.17 h / Inert atmosphere

5.2: 1 h / -20 °C / Inert atmosphere

6.1: 1H-imidazole / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

6.2: 12 h / 20 °C / Inert atmosphere

7.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone; water / dichloromethane / 0.33 h / 0 - 20 °C / Inert atmosphere

With 1H-imidazole; copper(l) iodide; water; sodium hydride; potassium carbonate; acetic acid; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1002/hlca.201200064

Reference yield:

: 1401872-16-9
(4R,5S)-5-(benzyloxy)-8-[(4-methoxybenzyl)oxy]oct-1-en-4-ol

: 1401872-17-0
(4S,5R)-4-(benzyloxy)-5-{[(tert-butyl)(diphenyl)silyl]oxy}oct-7-en-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1H-imidazole / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

1.2: 12 h / 20 °C / Inert atmosphere

2.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone; water / dichloromethane / 0.33 h / 0 - 20 °C / Inert atmosphere

With 1H-imidazole; water; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane;
DOI:10.1002/hlca.201200064