4-((2R,4S)-3-Benzoyl-2-tert-butyl-1,4-dimethyl-5-oxo-imidazolidin-4-yl)-benzonitrile

Base Information

Chemical Name:4-((2R,4S)-3-Benzoyl-2-tert-butyl-1,4-dimethyl-5-oxo-imidazolidin-4-yl)-benzonitrile
CAS No.:201608-23-3
Molecular Formula:C₂₃H₂₅N₃O₂
Molecular Weight:375.47
Hs Code.:

Synonyms:4-((2R,4S)-3-Benzoyl-2-tert-butyl-1,4-dimethyl-5-oxo-imidazolidin-4-yl)-benzonitrile

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Chemical Property of 4-((2R,4S)-3-Benzoyl-2-tert-butyl-1,4-dimethyl-5-oxo-imidazolidin-4-yl)-benzonitrile

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Technology Process of 4-((2R,4S)-3-Benzoyl-2-tert-butyl-1,4-dimethyl-5-oxo-imidazolidin-4-yl)-benzonitrile

There total 10 articles about 4-((2R,4S)-3-Benzoyl-2-tert-butyl-1,4-dimethyl-5-oxo-imidazolidin-4-yl)-benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 7677-24-9
trimethylsilyl cyanide

: 201608-21-1
Trifluoro-methanesulfonic acid 4-((2R,4S)-3-benzoyl-2-tert-butyl-1,4-dimethyl-5-oxo-imidazolidin-4-yl)-phenyl ester

: 201608-23-3
4-((2R,4S)-3-Benzoyl-2-tert-butyl-1,4-dimethyl-5-oxo-imidazolidin-4-yl)-benzonitrile

Guidance literature:: With triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾;
DOI:10.1039/a704704e

Reference yield:

: 22818-40-2
D-4-hydroxyphenylglycine

: 201608-23-3
4-((2R,4S)-3-Benzoyl-2-tert-butyl-1,4-dimethyl-5-oxo-imidazolidin-4-yl)-benzonitrile

Guidance literature:: Multi-step reaction with 9 steps

2: HCl / Ambient temperature

3: methanol; ethanol / 30 h / Ambient temperature

4: pentane / 3 h / Heating

5: 1.) HCl, 2.) Et₃N / 1.) MeOH, 3 h, r.t.; 2.) Ch₂Cl₂, 6 h, r.t.

6: 92 percent / LDA / tetrahydrofuran / 1.) 1 h, 2.) 2 h

7: H₂ / Pd/C / methanol / 3 h

8: 2,6-lutidine, DMAP / CH₂Cl₂ / 2 h / -30 °C

9: 98 percent / Et₃N / (Ph₃P)4Pd

With 2,6-dimethylpyridine; hydrogenchloride; dmap; hydrogen; triethylamine; lithium diisopropyl amide; palladium on activated charcoal; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; dichloromethane; pentane;
DOI:10.1039/a704704e

Reference yield:

: 69489-40-3
D-2-[p-(benzyloxy)phenyl]glycine

: 201608-23-3
4-((2R,4S)-3-Benzoyl-2-tert-butyl-1,4-dimethyl-5-oxo-imidazolidin-4-yl)-benzonitrile

Guidance literature:: Multi-step reaction with 8 steps

1: HCl / Ambient temperature

2: methanol; ethanol / 30 h / Ambient temperature

3: pentane / 3 h / Heating

4: 1.) HCl, 2.) Et₃N / 1.) MeOH, 3 h, r.t.; 2.) Ch₂Cl₂, 6 h, r.t.

5: 92 percent / LDA / tetrahydrofuran / 1.) 1 h, 2.) 2 h

6: H₂ / Pd/C / methanol / 3 h

7: 2,6-lutidine, DMAP / CH₂Cl₂ / 2 h / -30 °C

8: 98 percent / Et₃N / (Ph₃P)4Pd

With 2,6-dimethylpyridine; hydrogenchloride; dmap; hydrogen; triethylamine; lithium diisopropyl amide; palladium on activated charcoal; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; dichloromethane; pentane;
DOI:10.1039/a704704e