tert-butyl 1-(4-(4-methoxy-2-(2-methoxyethylamino)-5-phenylfuro[2,3-d]pyrimidin-6-yl)phenyl)cyclobutylcarbamate

Base Information

Chemical Name:tert-butyl 1-(4-(4-methoxy-2-(2-methoxyethylamino)-5-phenylfuro[2,3-d]pyrimidin-6-yl)phenyl)cyclobutylcarbamate
CAS No.:1301611-25-5
Molecular Formula:C₃₁H₃₆N₄O₅
Molecular Weight:544.651
Hs Code.:

Synonyms:tert-butyl 1-(4-(4-methoxy-2-(2-methoxyethylamino)-5-phenylfuro[2,3-d]pyrimidin-6-yl)phenyl)cyclobutylcarbamate

Suppliers and Price of tert-butyl 1-(4-(4-methoxy-2-(2-methoxyethylamino)-5-phenylfuro[2,3-d]pyrimidin-6-yl)phenyl)cyclobutylcarbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl 1-(4-(4-methoxy-2-(2-methoxyethylamino)-5-phenylfuro[2,3-d]pyrimidin-6-yl)phenyl)cyclobutylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl 1-(4-(4-methoxy-2-(2-methoxyethylamino)-5-phenylfuro[2,3-d]pyrimidin-6-yl)phenyl)cyclobutylcarbamate

There total 7 articles about tert-butyl 1-(4-(4-methoxy-2-(2-methoxyethylamino)-5-phenylfuro[2,3-d]pyrimidin-6-yl)phenyl)cyclobutylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1301610-66-1
tert-butyl (1-(4-(4-methoxy-2-(methylsulfonyl)-5-phenylfuro[2,3-d]pyrimidin-6-yl)phenyl)cyclobutyl)carbamate

: 109-85-3
2-methoxyethylamine

: 1301611-25-5
tert-butyl 1-(4-(4-methoxy-2-(2-methoxyethylamino)-5-phenylfuro[2,3-d]pyrimidin-6-yl)phenyl)cyclobutylcarbamate

Guidance literature:: In N,N-dimethyl-formamide; at 100 ℃; for 0.333333h; Microwave irradiation;

Reference yield:

: 10428-49-6
β-chloro-β-nitrostyrene

: 1301611-25-5
tert-butyl 1-(4-(4-methoxy-2-(2-methoxyethylamino)-5-phenylfuro[2,3-d]pyrimidin-6-yl)phenyl)cyclobutylcarbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / ethanol / 96 h / Inert atmosphere; Reflux

2.1: trichlorophosphate / 1.5 h / Reflux

3.1: N,N-dimethyl-formamide / 1.5 h / 80 °C / Inert atmosphere

4.1: n-butyllithium / tetrahydrofuran; hexanes / 1 h / -78 °C / Inert atmosphere

4.2: 1 h / -78 °C / Inert atmosphere

4.3: 20 °C / Inert atmosphere

5.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 1.5 h / 90 °C / Inert atmosphere

6.1: Oxone / water; tetrahydrofuran; methanol / 20 - 50 °C

7.1: N,N-dimethyl-formamide / 0.33 h / 100 °C / Microwave irradiation

With Oxone; potassium phosphate; n-butyllithium; 1,8-diazabicyclo[5.4.0]undec-7-ene; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; hexanes; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1301610-61-6
2-methylthio-5-phenylfuro[2,3-d]pyrimidin-4(3H)-one

: 1301611-25-5
tert-butyl 1-(4-(4-methoxy-2-(2-methoxyethylamino)-5-phenylfuro[2,3-d]pyrimidin-6-yl)phenyl)cyclobutylcarbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: trichlorophosphate / 1.5 h / Reflux

2.1: N,N-dimethyl-formamide / 1.5 h / 80 °C / Inert atmosphere

3.1: n-butyllithium / tetrahydrofuran; hexanes / 1 h / -78 °C / Inert atmosphere

3.2: 1 h / -78 °C / Inert atmosphere

3.3: 20 °C / Inert atmosphere

4.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 1.5 h / 90 °C / Inert atmosphere

5.1: Oxone / water; tetrahydrofuran; methanol / 20 - 50 °C

6.1: N,N-dimethyl-formamide / 0.33 h / 100 °C / Microwave irradiation

With Oxone; potassium phosphate; n-butyllithium; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; hexanes; water; N,N-dimethyl-formamide;