1,3-dioxolane-4-acetamide, 5-<2-cyclohexyl-1-<<(1,1-dimethylethoxy)carbonyl>amino>ethyl>-2,2-dimethyl-α-(1-methylethyl)-N-<5-(hexahydro-2-oxo-1H-thieno<3,4-d>imidazol-4-yl)-1-oxopentyl>-, <3aS-<3aα,4β(1R,2R,3S,4S),6aα>>-

Base Information

Chemical Name:1,3-dioxolane-4-acetamide, 5-<2-cyclohexyl-1-<<(1,1-dimethylethoxy)carbonyl>amino>ethyl>-2,2-dimethyl-α-(1-methylethyl)-N-<5-(hexahydro-2-oxo-1H-thieno<3,4-d>imidazol-4-yl)-1-oxopentyl>-, <3aS-<3aα,4β(1R*,2R*,3S*,4S*),6aα>>-
CAS No.:153805-29-9
Molecular Formula:C₃₉H₆₉N₅O₇S
Molecular Weight:752.072
Hs Code.:

1,3-dioxolane-4-acetamide, 5-<2-cyclohexyl-1-<<(1,1-dimethylethoxy)carbonyl>amino>ethyl>-2,2-dimethyl-α-(1-methylethyl)-N-<5-(hexahydro-2-oxo-1H-thieno<3,4-d>imidazol-4-yl)-1-oxopentyl>-, <3aS-<3aα,4β(1R*,2R*,3S*,4S*),6aα>>-

Synonyms:1,3-dioxolane-4-acetamide, 5-<2-cyclohexyl-1-<<(1,1-dimethylethoxy)carbonyl>amino>ethyl>-2,2-dimethyl-α-(1-methylethyl)-N-<5-(hexahydro-2-oxo-1H-thieno<3,4-d>imidazol-4-yl)-1-oxopentyl>-, <3aS-<3aα,4β(1R*,2R*,3S*,4S*),6aα>>-

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Chemical Property of 1,3-dioxolane-4-acetamide, 5-<2-cyclohexyl-1-<<(1,1-dimethylethoxy)carbonyl>amino>ethyl>-2,2-dimethyl-α-(1-methylethyl)-N-<5-(hexahydro-2-oxo-1H-thieno<3,4-d>imidazol-4-yl)-1-oxopentyl>-, <3aS-<3aα,4β(1R*,2R*,3S*,4S*),6aα>>-

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Technology Process of 1,3-dioxolane-4-acetamide, 5-<2-cyclohexyl-1-<<(1,1-dimethylethoxy)carbonyl>amino>ethyl>-2,2-dimethyl-α-(1-methylethyl)-N-<5-(hexahydro-2-oxo-1H-thieno<3,4-d>imidazol-4-yl)-1-oxopentyl>-, <3aS-<3aα,4β(1R*,2R*,3S*,4S*),6aα>>-

There total 5 articles about 1,3-dioxolane-4-acetamide, 5-<2-cyclohexyl-1-<<(1,1-dimethylethoxy)carbonyl>amino>ethyl>-2,2-dimethyl-α-(1-methylethyl)-N-<5-(hexahydro-2-oxo-1H-thieno<3,4-d>imidazol-4-yl)-1-oxopentyl>-, <3aS-<3aα,4β(1R*,2R*,3S*,4S*),6aα>>- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 112190-45-1
2(R)-<5(R)-<1(S)-<(tert-butyloxycarbonyl)amino>-2-cyclohexylethyl>-2,2-dimethyl-4(R)-dioxolanyl>-3-methylbutanoic acid

: 153805-28-8
1H-thieno<3,4-d>imidazole-4-pentanamide, hexahydro-2-oxo-N-<2-amino-3-methylpentyl>-, <3aS-<3aα,4β(1R*),6aα>>-

: 153805-29-9
1,3-dioxolane-4-acetamide, 5-<2-cyclohexyl-1-<<(1,1-dimethylethoxy)carbonyl>amino>ethyl>-2,2-dimethyl-α-(1-methylethyl)-N-<5-(hexahydro-2-oxo-1H-thieno<3,4-d>imidazol-4-yl)-1-oxopentyl>-, <3aS-<3aα,4β(1R*,2R*,3S*,4S*),6aα>>-

Guidance literature:: With diethyl cyanophosphonate; N-ethyl-N,N-diisopropylamine; In dichloromethane; for 18h; Ambient temperature;
DOI:10.1021/jm00028a013

Reference yield:

: 141321-52-0,141321-53-1,141321-50-8,106946-74-1,545433-88-3
N-(tert-butoxycarbonyl)-L-isoleucinol

: 153805-29-9
1,3-dioxolane-4-acetamide, 5-<2-cyclohexyl-1-<<(1,1-dimethylethoxy)carbonyl>amino>ethyl>-2,2-dimethyl-α-(1-methylethyl)-N-<5-(hexahydro-2-oxo-1H-thieno<3,4-d>imidazol-4-yl)-1-oxopentyl>-, <3aS-<3aα,4β(1R*,2R*,3S*,4S*),6aα>>-

Guidance literature:: Multi-step reaction with 5 steps

1: 77 percent / ZnN₆-pyridine2, Ph₃P, diispropyl azodicarboxylate / toluene / 3 h / Ambient temperature

2: 76 percent / H₂ / Pd/CaCO₃ / methanol / 4 h / 760 Torr

3: 75 percent / dimethylformamide / 14 h / Ambient temperature

4: 99 percent / CF₃CO₂H / CH₂Cl₂ / 3 h / Ambient temperature

5: 42 percent / iPr₂EtN, (EtO)2P(O)CN / CH₂Cl₂ / 18 h / Ambient temperature

With diethyl cyanophosphonate; di-isopropyl azodicarboxylate; ZnN₆-pyridine2; hydrogen; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; Lindlar's catalyst; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00028a013

Reference yield:

: 124590-30-3
carbamic acid, <1-(azidomethyl)-2-methylbutyl>-, 1,1-dimethylethyl ester,

: 153805-29-9
1,3-dioxolane-4-acetamide, 5-<2-cyclohexyl-1-<<(1,1-dimethylethoxy)carbonyl>amino>ethyl>-2,2-dimethyl-α-(1-methylethyl)-N-<5-(hexahydro-2-oxo-1H-thieno<3,4-d>imidazol-4-yl)-1-oxopentyl>-, <3aS-<3aα,4β(1R*,2R*,3S*,4S*),6aα>>-

Guidance literature:: Multi-step reaction with 4 steps

1: 76 percent / H₂ / Pd/CaCO₃ / methanol / 4 h / 760 Torr

2: 75 percent / dimethylformamide / 14 h / Ambient temperature

3: 99 percent / CF₃CO₂H / CH₂Cl₂ / 3 h / Ambient temperature

4: 42 percent / iPr₂EtN, (EtO)2P(O)CN / CH₂Cl₂ / 18 h / Ambient temperature

With diethyl cyanophosphonate; hydrogen; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; Lindlar's catalyst; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00028a013