Boc-D-allo-isoleucinol

Base Information

• Chemical Name: Boc-D-allo-isoleucinol
• CAS No.: 141321-52-0
• Molecular Formula: C₁₁H₂₃NO₃
• Molecular Weight: 217.309
• Mol file: 141321-52-0.mol

Synonyms:

Chemical Property of Boc-D-allo-isoleucinol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Boc-D-allo-isoleucinol

There total 26 articles about Boc-D-allo-isoleucinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N-(tert-butyloxycarbonyl)-L-isoleucine (13139-16-7) → N-(tert-butoxycarbonyl)-L-isoleucinol (141321-52-0,141321-53-1,141321-50-8,106946-74-1,545433-88-3)

Guidance literature:

With borane-THF; In tetrahydrofuran; at 0 - 20 ℃; for 5.83333h; Inert atmosphere;

DOI:10.1016/j.tet.2017.03.006

Reference yield: 97.0%

N-(tert-butoxycarbonyl)isoleucine methyl ester (17901-01-8) → N-(tert-butoxycarbonyl)-L-isoleucinol (141321-52-0,141321-53-1,141321-50-8,106946-74-1,545433-88-3)

Guidance literature:

With lithium borohydride; In 1,2-dimethoxyethane;

DOI:10.1016/0223-5234(89)90055-X

Reference yield: 95.0%

N-tert-butoxycarbonyl-D-alloisoleucine (13139-16-7,35264-07-4,55721-65-8,55780-90-0,116194-21-9) → Boc-D-allo-isoleucinol (106946-74-1,141321-50-8,141321-53-1,141321-52-0,545433-88-3)

Guidance literature:

With diborane; In tetrahydrofuran; for 1h; 0 deg C to r. t.;

DOI:10.1021/jo00037a012

upstream raw materials:

N-(tert-butyloxycarbonyl)-L-isoleucine

N-(tert-butoxycarbonyl)isoleucine methyl ester

C₁₅H₂₇NO₆

L-isoleucine

Downstream raw materials:

N-(t-butoxycarbonyl)-isoleucine aldehyde

(S) 1-hydroxy-O-(p-toluenesulfonyl)-2-amino-N-(tert-butyloxycarbonyl)-3-methyl-pentane

L-idonamide, 6-cyclohexyl-2,5,6-trideoxy-N-<1-<<<5-(hexahydro-2-oxo-1H-thieno<3,4-d>imidazol-4-yl)-1-oxopentyl>amino>methyl>-2-methylbutyl>-2-(1-methylethyl)-5-amino-, <3aS-<3aα,4β(1R*,2R*),6aα>>-

1,3-dioxolane-4-acetamide, 5-<2-cyclohexyl-1-<<(1,1-dimethylethoxy)carbonyl>amino>ethyl>-2,2-dimethyl-α-(1-methylethyl)-N-<5-(hexahydro-2-oxo-1H-thieno<3,4-d>imidazol-4-yl)-1-oxopentyl>-, <3aS-<3aα,4β(1R*,2R*,3S*,4S*),6aα>>-