(1S,2S)-N-(4-methoxyphenyl)-1-(4-cyanophenyl)-2-(methylsulfenyl)-2-phenylethylamine

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Chemical Name:(1S,2S)-N-(4-methoxyphenyl)-1-(4-cyanophenyl)-2-(methylsulfenyl)-2-phenylethylamine
CAS No.:1326705-23-0
Molecular Formula:C₂₃H₂₂N₂OS
Molecular Weight:374.506
Hs Code.:

Synonyms:(1S,2S)-N-(4-methoxyphenyl)-1-(4-cyanophenyl)-2-(methylsulfenyl)-2-phenylethylamine

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Chemical Property of (1S,2S)-N-(4-methoxyphenyl)-1-(4-cyanophenyl)-2-(methylsulfenyl)-2-phenylethylamine

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Technology Process of (1S,2S)-N-(4-methoxyphenyl)-1-(4-cyanophenyl)-2-(methylsulfenyl)-2-phenylethylamine

There total 4 articles about (1S,2S)-N-(4-methoxyphenyl)-1-(4-cyanophenyl)-2-(methylsulfenyl)-2-phenylethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1326705-12-7
(1S,2S)-N-(4-methoxyphenyl)-1-(4-cyanophenyl)-2-(methylsulfenyl)-2-{2-[(S)-p-tolylsulfinyl]phenyl}ethylamine

: 1326705-23-0
(1S,2S)-N-(4-methoxyphenyl)-1-(4-cyanophenyl)-2-(methylsulfenyl)-2-phenylethylamine

Guidance literature:: (1S,2S)-N-(4-methoxyphenyl)-1-(4-cyanophenyl)-2-(methylsulfenyl)-2-{2-[(S)-p-tolylsulfinyl]phenyl}ethylamine; With tert.-butyl lithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.0833333h; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; hexane; Inert atmosphere;
DOI:10.1021/ol201696y

Reference yield:

: 105-07-7
4-cyanobenzaldehyde

: 1326705-23-0
(1S,2S)-N-(4-methoxyphenyl)-1-(4-cyanophenyl)-2-(methylsulfenyl)-2-phenylethylamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: Molecular sieve

2.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 0.02 h / -78 °C / Inert atmosphere

2.2: 0.02 h / -78 °C / Inert atmosphere

3.1: tert.-butyl lithium / tetrahydrofuran; hexane / 0.08 h / -78 °C / Inert atmosphere

3.2: Inert atmosphere

With n-butyllithium; tert.-butyl lithium; diisopropylamine; In tetrahydrofuran; hexane;
DOI:10.1021/ol201696y

Reference yield:

: 114046-25-2,20256-89-7
4-(((4-methoxyphenyl)imino)methyl)benzonitrile

: 1326705-23-0
(1S,2S)-N-(4-methoxyphenyl)-1-(4-cyanophenyl)-2-(methylsulfenyl)-2-phenylethylamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 0.02 h / -78 °C / Inert atmosphere

1.2: 0.02 h / -78 °C / Inert atmosphere

2.1: tert.-butyl lithium / tetrahydrofuran; hexane / 0.08 h / -78 °C / Inert atmosphere

2.2: Inert atmosphere

With n-butyllithium; tert.-butyl lithium; diisopropylamine; In tetrahydrofuran; hexane;
DOI:10.1021/ol201696y