N-Cyclopropyl-4-methyl-N-<6-(4-methyl-1-piperazinyl)-5-(trifluoromethyl)-2-pyridinyl>benzenesulfonamide

Base Information

• Chemical Name: N-Cyclopropyl-4-methyl-N-<6-(4-methyl-1-piperazinyl)-5-(trifluoromethyl)-2-pyridinyl>benzenesulfonamide
• CAS No.: 132844-43-0
• Molecular Formula: C₂₁H₂₅F₃N₄O₂S
• Molecular Weight: 454.516

Synonyms:N-Cyclopropyl-4-methyl-N-<6-(4-methyl-1-piperazinyl)-5-(trifluoromethyl)-2-pyridinyl>benzenesulfonamide

Chemical Property of N-Cyclopropyl-4-methyl-N-<6-(4-methyl-1-piperazinyl)-5-(trifluoromethyl)-2-pyridinyl>benzenesulfonamide

Chemical Property:

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Technology Process of N-Cyclopropyl-4-methyl-N-<6-(4-methyl-1-piperazinyl)-5-(trifluoromethyl)-2-pyridinyl>benzenesulfonamide

There total 4 articles about N-Cyclopropyl-4-methyl-N-<6-(4-methyl-1-piperazinyl)-5-(trifluoromethyl)-2-pyridinyl>benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

1-methyl-piperazine (109-01-3) + N-Cyclopropyl-4-methyl-N-<6-chloro-5-(trifluoromethyl)-2-pyridinyl>benzenesulfonamide (132844-53-2) → N-Cyclopropyl-4-methyl-N-<6-(4-methyl-1-piperazinyl)-5-(trifluoromethyl)-2-pyridinyl>benzenesulfonamide (132844-43-0)

Guidance literature:

In N,N-dimethyl-formamide; at 100 ℃; for 15h;

DOI:10.1002/jhet.5570270602

Reference yield:

2,6-dichloro-3-(trifluoromethyl)pyridine (55304-75-1) → N-Cyclopropyl-4-methyl-N-<6-(4-methyl-1-piperazinyl)-5-(trifluoromethyl)-2-pyridinyl>benzenesulfonamide (132844-43-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) NaH / 1) DMF, 80 deg C, 10 min 2) 80 deg C, 1 h

2: 86 percent / dimethylformamide / 15 h / 100 °C

With sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1002/jhet.5570270602

Reference yield:

N-Cyclopropyl-4-methylbenzenesulfonamide (65032-46-4) → N-Cyclopropyl-4-methyl-N-<6-(4-methyl-1-piperazinyl)-5-(trifluoromethyl)-2-pyridinyl>benzenesulfonamide (132844-43-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) NaH / 1) DMF, 80 deg C, 10 min 2) 80 deg C, 1 h

2: 86 percent / dimethylformamide / 15 h / 100 °C

With sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1002/jhet.5570270602

upstream raw materials:

1-methyl-piperazine

N-Cyclopropyl-4-methyl-N-<6-chloro-5-(trifluoromethyl)-2-pyridinyl>benzenesulfonamide

2,6-dichloro-3-(trifluoromethyl)pyridine

N-Cyclopropyl-4-methylbenzenesulfonamide

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