55304-75-1

Basic information

• Product Name: 2,6-Dichloro-3-(trifluoromethyl)pyridine
• Synonyms: 2,6-Dichloro-3-(trifluoromethyl)pyridine,97%;2,6-Dichloro-alpha,alpha,alpha-trifluoro-3-picoline;2,6-DICHLORO-3-(TRIFLUOROMETHYL)PYRIDINE;2,6-DICHLORO-3-(TRIFLUOROMETHYL)PYRIDINE, PURISS, 98%;2,6-DICHLORO-3-(TRIFLUOROMETHYL)PYRIDIN&;2,6-Dichloro-3-[trifluoromethy;2,6-DICHLORO-3-[TRIFLUOROMETHYL]-PYRIDINE 99+%
• CAS NO: 55304-75-1
• Molecular Formula: C₆H₂Cl₂F₃N
• Molecular Weight: 215.99
• EINECS: 259-585-8
• Product Categories: Fluorine series;Pyridine;C6Heterocyclic Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Pyridines
• Mol File: 55304-75-1.mol
• Article Data: 8

Chemical Properties

• Melting Point: 194 °C
• Boiling Point: 194-196 °C(lit.)
• Flash Point: 218 °F
• Appearance: /
• Density: 2.008 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.162mmHg at 25°C
• Refractive Index: n20/D 1.4850(lit.)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: -4.84±0.10(Predicted)
• BRN: 1570287
• CAS DataBase Reference: 2,6-Dichloro-3-(trifluoromethyl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-Dichloro-3-(trifluoromethyl)pyridine(55304-75-1)
• EPA Substance Registry System: 2,6-Dichloro-3-(trifluoromethyl)pyridine(55304-75-1)

Safety Data

• Hazard Codes: T,Xi
• Statements: 25-36/37/38
• Safety Statements: 26-36/37-45
• RIDADR: UN 2810 6.1/PG 3
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 55304-75-1(Hazardous Substances Data)

Usage

Chemical Properties

Colorless liquid

InChI:InChI=1/C6H2Cl2F3N/c7-4-2-1-3(5(8)12-4)6(9,10)11/h1-2H

Upstream product

• 261956-65-4 2-chloro-5-trifluoromethylpyridine 1-oxide 
• 52334-81-3 2-chloro-5-trifluoromethylpyridine 
• 108-99-6 3-Methylpyridine 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 148493-37-2 2,6-dichloro-3-iodo-pyridine 
• 55366-30-8 2,6-dichloro-3-(trichloromethyl)pyridine 
• 7783-56-4 antimony(III) fluoride 
• 87-69-4 tartaric acid 

Downstream Products

• 78743-29-0 3-chloro-4-(5-trifluoromethyl-6-chloro-pyridin-2-yloxy)aniline 
• 132844-53-2 N-Cyclopropyl-4-methyl-N-<6-chloro-5-(trifluoromethyl)-2-pyridinyl>benzenesulfonamide 
• 136353-03-2 2-chloro-6-methoxy-3-(trifluoromethyl)pyridine 
• 136353-04-3 6-chloro-2-methoxy-3-(trifluoromethyl)pyridine 
• 132844-56-5 <amino>methylene>propanedioic acid diethyl ester 
• 100366-75-4 2‐iodo‐5‐(trifluoromethyl)pyridine 
• 132844-49-6 2,6-Bis(phenylthio)-3-(trifluoromethyl)pyridine 
• 132844-47-4 6-Chloro-N-cyclopropyl-5-(trifluoromethyl)-2-pyridineamine 
• 132844-46-3 6-Chloro-N-cyclopropyl-3-(trifluoromethyl)-2-pyridineamine 
• 683243-59-6 (6-chloro-5-trifluoromethyl-pyridin-2-yl)-(4-methoxy-benzyl)-amine, trifluoroacetic acid salt 
• 1135438-50-4 1-(2,3-dichlorobenzyl)-4-[6-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazine 
• 1135438-49-1 1-(2-chloro-6-fluorobenzyl)-4-[6-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazine 
• 1203719-15-6 1-(2,6-difluorobenzyl)-4-[6-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazine 
• 1135438-82-2 1-(4-iodobenzyl)-4-[6-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazine 

Relevant articles and documents

SUBSTITUTED AZOLE DIONE COMPOUNDS WITH ANTIVIRAL ACTIVITY

Provided herein are methods of using substituted azole dione compounds for treatment of viral infections.

METHOD FOR PREPARING 2,3-DICHLORO-5-TRIFLUOROMETHYLPYRIDINE WITH HIGH SELECTIVITY

The present invention discloses a method for preparing 2,3-dichloro-5-trifluoromethylpyridine, comprising at a temperature of 100?150° C. and a pressure of 0.5?5.0 MP, in presence of at least one catalyst selected from supported metal chloride, supported zeolite molecular sieve and supported heteropolyacid, 2-chloro-5-trifluoromethylpyridine reacts with chlorine gas to obtain 2,3-dichloro-5-trifluoromethylpyridine. The preparing method provided by the present invention has advantages such as high selectivity of desired product, high utilization rate of chlorine gas, moderate process condition, simple operation and less three wastes. The present invention also discloses a preparing method for preparing 2-chloro-5-trifluoromethylpyridine, which is capable of reducing unit consumption, reducing separation cost, and improving safety compared to the prior art.

Compounds with anti-cancer activity

Novel substituted azole diones are provided that kill cells, suppress cell proliferation, suppress cell growth, abrogate the cell cycle G2 checkpoint and/or cause adaptation to G2 cell cycle arrest. Methods of making and using the invention compounds are provided. The invention provides substituted azole diones to treat cell proliferation disorders. The invention includes the use of substituted azole diones to selectively kill or suppress cancer cells without additional anti-cancer treatment. The invention includes the use of cell cycle G2-checkpoint-abrogating substituted azole diones to selectively sensitize cancer cells to DNA damaging reagents, treatments and/or other types of anti-cancer reagents.