N-{2-butyl-3-[4-(3-di-[²H₉]-butylamino-propoxy)-benzoyl]-benzofuran-5-yl}-methanesulfonamide hydrochloride

Base Information

• Chemical Name: N-{2-butyl-3-[4-(3-di-[²H₉]-butylamino-propoxy)-benzoyl]-benzofuran-5-yl}-methanesulfonamide hydrochloride
• CAS No.: 1542232-60-9
• Molecular Formula: C₃₁H₄₄N₂O₅S*ClH
• Molecular Weight: 611.085

Synonyms:N-{2-butyl-3-[4-(3-di-[²H₉]-butylamino-propoxy)-benzoyl]-benzofuran-5-yl}-methanesulfonamide hydrochloride

Chemical Property of N-{2-butyl-3-[4-(3-di-[²H₉]-butylamino-propoxy)-benzoyl]-benzofuran-5-yl}-methanesulfonamide hydrochloride

Chemical Property:

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Technology Process of N-{2-butyl-3-[4-(3-di-[²H₉]-butylamino-propoxy)-benzoyl]-benzofuran-5-yl}-methanesulfonamide hydrochloride

There total 3 articles about N-{2-butyl-3-[4-(3-di-[²H₉]-butylamino-propoxy)-benzoyl]-benzofuran-5-yl}-methanesulfonamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

(5-amino-2-butyl-benzofuran-3-yl)-[4-(3-di-[2H9]-butylaminopropoxy)-phenyl]-methanone (1542232-50-7) + methanesulfonyl chloride (124-63-0) → N-{2-butyl-3-[4-(3-di-[2H9]-butylamino-propoxy)-benzoyl]-benzofuran-5-yl}-methanesulfonamide hydrochloride (1542232-60-9)

Guidance literature:

(5-amino-2-butyl-benzofuran-3-yl)-[4-(3-di-[²H₉]-butylaminopropoxy)-phenyl]-methanone; methanesulfonyl chloride; With ammonia; In tetrahydrofuran; tert-butyl methyl ether; water; at 20 ℃;

With hydrogenchloride; In diethyl ether;

DOI:10.1002/jlcr.3090

Reference yield:

[4-(3-bromo-propoxy)-phenyl]-(2-butyl-5-nitro-benzofuran-3-yl)-methanone (141645-38-7) → N-{2-butyl-3-[4-(3-di-[2H9]-butylamino-propoxy)-benzoyl]-benzofuran-5-yl}-methanesulfonamide hydrochloride (1542232-60-9)

Guidance literature:

Multi-step reaction with 3 steps

1: ethanol / Reflux

2: tin(II) chloride dihdyrate / ethanol / 80 °C / Inert atmosphere

3: ammonia / tetrahydrofuran; water; tert-butyl methyl ether / 20 °C

With tin(II) chloride dihdyrate; ammonia; In tetrahydrofuran; ethanol; tert-butyl methyl ether; water;

DOI:10.1002/jlcr.3090

Reference yield:

(2-butyl-5-nitro-benzofuran-3-yl)-[4-(3-di-[2H9]-butylamino-propoxy)-phenyl]-methanone (1542232-42-7) → N-{2-butyl-3-[4-(3-di-[2H9]-butylamino-propoxy)-benzoyl]-benzofuran-5-yl}-methanesulfonamide hydrochloride (1542232-60-9)

Guidance literature:

Multi-step reaction with 2 steps

1: tin(II) chloride dihdyrate / ethanol / 80 °C / Inert atmosphere

2: ammonia / tetrahydrofuran; water; tert-butyl methyl ether / 20 °C

With tin(II) chloride dihdyrate; ammonia; In tetrahydrofuran; ethanol; tert-butyl methyl ether; water;

DOI:10.1002/jlcr.3090

upstream raw materials:

[4-(3-bromo-propoxy)-phenyl]-(2-butyl-5-nitro-benzofuran-3-yl)-methanone

(2-butyl-5-nitro-benzofuran-3-yl)-[4-(3-di-[²H₉]-butylamino-propoxy)-phenyl]-methanone

(5-amino-2-butyl-benzofuran-3-yl)-[4-(3-di-[²H₉]-butylaminopropoxy)-phenyl]-methanone

methanesulfonyl chloride

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