ALPHA,BETA,BETA-2,6-DIMETHYLCYCLOHEXANOL

Base Information

• Chemical Name: ALPHA,BETA,BETA-2,6-DIMETHYLCYCLOHEXANOL
• CAS No.: 42846-29-7
• Molecular Formula: C8H16 O
• Molecular Weight: 128.214
• Mol file: 42846-29-7.mol

Synonyms:trans-2-trans-6-Dimethylcyclohexanol

Chemical Property of ALPHA,BETA,BETA-2,6-DIMETHYLCYCLOHEXANOL

Chemical Property:

• Boiling Point: 172 °C
• PSA: 20.23000
• LogP: 1.80340

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ALPHA,BETA,BETA-2,6-DIMETHYLCYCLOHEXANOL

There total 20 articles about ALPHA,BETA,BETA-2,6-DIMETHYLCYCLOHEXANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

2,6-dimethylcyclohexanone (2816-57-1) → 2,6-dimethylcyclohexanol (5337-72-4,39170-83-7) + cis,cis-2,6-dimethylcyclohexanol (39170-84-8,39170-83-7) + trans,trans-2,6-dimethylcyclohexanol (42846-29-7,39170-83-7)

Guidance literature:

With hydrogen; Nic; In ethanol; at 25 ℃; under 760 Torr;

DOI:10.1021/jo01298a037

Reference yield: 42.0%

cis-2,6-dimethylcyclohexanone (766-42-7,471256-22-1) → (1r*,2R*,6S*)-2,6-dimethylcyclohexanol (42846-29-7,39170-83-7) + cis,cis-2,6-dimethylcyclohexanol (39170-84-8,39170-83-7)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1124/jpet.115.228890

Reference yield: 17.7%

cis-2,6-dimethylcyclohexanone (766-42-7,471256-22-1) → (1r*,2R*,6S*)-2,6-dimethylcyclohexanol (42846-29-7,39170-83-7)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 5 - 20 ℃; for 0.5h;

upstream raw materials:

2,6-dimethylcyclohexanone

2.6-dimethylphenol

cis,cis-2,6-dimethylcyclohexanol

trans,trans-2,6-dimethylcyclohexanol

Downstream raw materials:

cis-2,6-dimethylcyclohexanone

trans-2,6-dimethylcyclohexanone

r-1-methoxy-t-2,t-6-dimethylcyclohexane

(1r*,2R*,6S*)-2,6-dimethylcyclohexanol

Refernces

• 1、 Chowdhury, Luvana,Croft, Celine J.,Goel, Shikha,Zaman, Naina,Tai, Angela C.-S.,Walch, Erin M.,Smith, Kelly,Page, Alexandra,Shea, Kevin M.,Hall, C. Dennis,Jishkariani,Pillai, Girinath G.,Hall, Adam C.. "Differential potency of 2,6-dimethylcyclohexanol isomers for positive modulation of GABAA receptor currents". . p. 570 - 579. Retrieved 2016/07/06.
• 2、 Ohkuma, Takeshi,Ooka, Hirohito,Yamakawa, Masashi,Ikariya, Takao,Noyori, Ryoji. "Stereoselective hydrogenation of simple ketones catalyzed by ruthenium(II) complexes". . p. 4872 - 4873. Retrieved 2007/10/03.