7a-hydroxy-2-methyl-6-(4-chlorophenyl)-3a,7a-dihydrofuro<3,2-b>pyran-5-one

Base Information

• Chemical Name: 7a-hydroxy-2-methyl-6-(4-chlorophenyl)-3a,7a-dihydrofuro<3,2-b>pyran-5-one
• CAS No.: 83307-96-4
• Molecular Formula: C₁₄H₁₁ClO₄
• Molecular Weight: 278.692
• Mol file: 83307-96-4.mol

Synonyms:7a-hydroxy-2-methyl-6-(4-chlorophenyl)-3a,7a-dihydrofuro<3,2-b>pyran-5-one

Chemical Property of 7a-hydroxy-2-methyl-6-(4-chlorophenyl)-3a,7a-dihydrofuro<3,2-b>pyran-5-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7a-hydroxy-2-methyl-6-(4-chlorophenyl)-3a,7a-dihydrofuro<3,2-b>pyran-5-one

There total 3 articles about 7a-hydroxy-2-methyl-6-(4-chlorophenyl)-3a,7a-dihydrofuro<3,2-b>pyran-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

(E)-2-(4-Chloro-phenyl)-3-(5-methyl-furan-2-yl)-acrylic acid (83307-79-3) → 7a-hydroxy-2-methyl-6-(4-chlorophenyl)-3a,7a-dihydrofuro<3,2-b>pyran-5-one (83307-96-4)

Guidance literature:

With air; In benzene; for 48h; Ambient temperature; Irradiation;

DOI:10.1016/0040-4020(82)85121-1

Reference yield:

4-chlorophenylacetic Acid (1878-66-6) → 7a-hydroxy-2-methyl-6-(4-chlorophenyl)-3a,7a-dihydrofuro<3,2-b>pyran-5-one (83307-96-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 58 percent / triethylamine; acetic anhydride / 1.5 h / Heating

2: 60 percent / air / benzene / 48 h / Ambient temperature; Irradiation

With air; In acetic anhydride; triethylamine; benzene;

DOI:10.1016/0040-4020(82)85121-1

Reference yield:

5-Methylfurfural (620-02-0) → 7a-hydroxy-2-methyl-6-(4-chlorophenyl)-3a,7a-dihydrofuro<3,2-b>pyran-5-one (83307-96-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 58 percent / triethylamine; acetic anhydride / 1.5 h / Heating

2: 60 percent / air / benzene / 48 h / Ambient temperature; Irradiation

With air; In acetic anhydride; triethylamine; benzene;

DOI:10.1016/0040-4020(82)85121-1

upstream raw materials:

(E)-2-(4-Chloro-phenyl)-3-(5-methyl-furan-2-yl)-acrylic acid

5-Methylfurfural

4-chlorophenylacetic Acid