N’-(8-chloro-2-(2,4-dimethoxybenzylamino)quinazolin-4-yl)-3,3-dimethoxypropanehydrazide

Base Information

• Chemical Name: N’-(8-chloro-2-(2,4-dimethoxybenzylamino)quinazolin-4-yl)-3,3-dimethoxypropanehydrazide
• CAS No.: 1616708-00-9
• Molecular Formula: C₂₂H₂₆ClN₅O₅
• Molecular Weight: 475.932
• Mol file: 1616708-00-9.mol

Synonyms:N’-(8-chloro-2-(2,4-dimethoxybenzylamino)quinazolin-4-yl)-3,3-dimethoxypropanehydrazide

Chemical Property of N’-(8-chloro-2-(2,4-dimethoxybenzylamino)quinazolin-4-yl)-3,3-dimethoxypropanehydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N’-(8-chloro-2-(2,4-dimethoxybenzylamino)quinazolin-4-yl)-3,3-dimethoxypropanehydrazide

There total 6 articles about N’-(8-chloro-2-(2,4-dimethoxybenzylamino)quinazolin-4-yl)-3,3-dimethoxypropanehydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4-Dimethoxybenzylamine (20781-20-8) + N'-(2,8-dichloroquinazolin-4-yl)-3,3-dimethoxypropanehydrazide (1616707-99-3) → N’-(8-chloro-2-(2,4-dimethoxybenzylamino)quinazolin-4-yl)-3,3-dimethoxypropanehydrazide (1616708-00-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; at 80 ℃;

Reference yield:

8-chloroquinazoline-2,4-diol (62484-22-4) → N’-(8-chloro-2-(2,4-dimethoxybenzylamino)quinazolin-4-yl)-3,3-dimethoxypropanehydrazide (1616708-00-9)

Guidance literature:

Multi-step reaction with 3 steps

1: trichlorophosphate; N,N-dimethyl-aniline / 16 h / 140 °C

2: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 2 h / 40 °C

3: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 80 °C

With N,N-dimethyl-aniline; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In 1,4-dioxane;

Reference yield:

2-amino-3-chlorobenzoic acid (6388-47-2) → N’-(8-chloro-2-(2,4-dimethoxybenzylamino)quinazolin-4-yl)-3,3-dimethoxypropanehydrazide (1616708-00-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 2 h / 200 °C

2: trichlorophosphate; N,N-dimethyl-aniline / 16 h / 140 °C

3: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 2 h / 40 °C

4: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 80 °C

With N,N-dimethyl-aniline; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In 1,4-dioxane;

upstream raw materials:

2,4-Dimethoxybenzylamine

N'-(2,8-dichloroquinazolin-4-yl)-3,3-dimethoxypropanehydrazide

3,3-dimethoxypropanehydrazide

methyl 3,3-dimethoxypropionate

Downstream raw materials:

7-chloro-N-(2,4-dimethoxybenzyl)-2-(2,2-dimethoxyethyl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine

2-(7-chloro-5-(2,4-dimethoxybenzylamino)-[1,2,4]triazolo[1,5-c]quinazolin-2-yl)acetaldehyde

7-chloro-5-(2,4-dimethoxyphenyl)-2-(2-(5-fluoroisoindolin-2-yl)ethyl)[1,2,4]triazolo[1,5-c]quinazoline