1-(5-(4-fluorophenyl)-3-(4-hydroxyphenyl)-4,5-dihydropyrazol-1-yl)ethanone

Base Information

Chemical Name:1-(5-(4-fluorophenyl)-3-(4-hydroxyphenyl)-4,5-dihydropyrazol-1-yl)ethanone
CAS No.:1085240-98-7
Molecular Formula:C₁₇H₁₅FN₂O₂
Molecular Weight:298.317
Hs Code.:

Synonyms:1-(5-(4-fluorophenyl)-3-(4-hydroxyphenyl)-4,5-dihydropyrazol-1-yl)ethanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(5-(4-fluorophenyl)-3-(4-hydroxyphenyl)-4,5-dihydropyrazol-1-yl)ethanone

Chemical Property:

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Technology Process of 1-(5-(4-fluorophenyl)-3-(4-hydroxyphenyl)-4,5-dihydropyrazol-1-yl)ethanone

There total 4 articles about 1-(5-(4-fluorophenyl)-3-(4-hydroxyphenyl)-4,5-dihydropyrazol-1-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.88%

: 64-19-7,77671-22-8
acetic acid

: 204974-32-3
(2E)-3-(4-fluorophenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one

: 1085240-98-7
1-(5-(4-fluorophenyl)-3-(4-hydroxyphenyl)-4,5-dihydropyrazol-1-yl)ethanone

Guidance literature:: With hydrazine hydrate; for 12h; Reflux;
DOI:10.1016/j.bmcl.2010.05.069

Reference yield:

: 64-19-7,77671-22-8
acetic acid

: 3-(4-fluorophenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one

: 1085240-98-7
1-(5-(4-fluorophenyl)-3-(4-hydroxyphenyl)-4,5-dihydropyrazol-1-yl)ethanone

Guidance literature:: With hydrazine hydrate; for 3h; Reflux;
DOI:10.1016/j.ejmech.2019.111638

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 1085240-98-7
1-(5-(4-fluorophenyl)-3-(4-hydroxyphenyl)-4,5-dihydropyrazol-1-yl)ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / methanol; water / 12 h / 20 °C

2: hydrazine hydrate / 3 h / Reflux

With hydrazine hydrate; sodium hydroxide; In methanol; water;
DOI:10.1016/j.ejmech.2019.111638