[(S)-1-(6-fluoro-1-phenyl-1H-benzoimidazol-2-yl)ethyl]methylcarbamic acid tert-butyl ester

Base Information

Chemical Name:[(S)-1-(6-fluoro-1-phenyl-1H-benzoimidazol-2-yl)ethyl]methylcarbamic acid tert-butyl ester
CAS No.:1393177-22-4
Molecular Formula:C₂₁H₂₄FN₃O₂
Molecular Weight:369.439
Hs Code.:

Synonyms:[(S)-1-(6-fluoro-1-phenyl-1H-benzoimidazol-2-yl)ethyl]methylcarbamic acid tert-butyl ester

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Chemical Property of [(S)-1-(6-fluoro-1-phenyl-1H-benzoimidazol-2-yl)ethyl]methylcarbamic acid tert-butyl ester

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Technology Process of [(S)-1-(6-fluoro-1-phenyl-1H-benzoimidazol-2-yl)ethyl]methylcarbamic acid tert-butyl ester

There total 5 articles about [(S)-1-(6-fluoro-1-phenyl-1H-benzoimidazol-2-yl)ethyl]methylcarbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: [(S)-1-(4-fluoro-2-phenylaminophenylcarbamoyl)ethyl]methylcarbamic acid tert-butyl ester

: 1393177-22-4
[(S)-1-(6-fluoro-1-phenyl-1H-benzoimidazol-2-yl)ethyl]methylcarbamic acid tert-butyl ester

Guidance literature:: [(S)-1-(4-fluoro-2-phenylaminophenylcarbamoyl)ethyl]methylcarbamic acid tert-butyl ester; With acetic acid; at 70 ℃; for 18h;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield:

: 62-53-3
aniline

: 1393177-22-4
[(S)-1-(6-fluoro-1-phenyl-1H-benzoimidazol-2-yl)ethyl]methylcarbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

1.2: 1 h / -78 °C

2.1: hydrogen / palladium 10% on activated carbon / industrial methylated spirits / 4 h / 20 °C

3.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-methyl-morpholine / dichloromethane / 2 h / 20 °C

3.2: 18 h / 20 °C

4.1: acetic acid / 18 h / 70 °C

With 4-methyl-morpholine; 1-hydroxy-7-aza-benzotriazole; hydrogen; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hexamethyldisilazane; palladium 10% on activated carbon; In tetrahydrofuran; industrial methylated spirits; dichloromethane;

Reference yield:

: 322-68-9
4-fluoro-2-(phenylamino)nitrobenzene

: 1393177-22-4
[(S)-1-(6-fluoro-1-phenyl-1H-benzoimidazol-2-yl)ethyl]methylcarbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen / palladium 10% on activated carbon / industrial methylated spirits / 4 h / 20 °C

2.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-methyl-morpholine / dichloromethane / 2 h / 20 °C

2.2: 18 h / 20 °C

3.1: acetic acid / 18 h / 70 °C

With 4-methyl-morpholine; 1-hydroxy-7-aza-benzotriazole; hydrogen; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium 10% on activated carbon; In industrial methylated spirits; dichloromethane;