9-<2'-O-Acetyl-3',5'-bis-O-(2,4-dichlorobenzyl)-β-D-ribofuranosyl>-6-chloro-9H-purin

Base Information

Chemical Name:9-<2'-O-Acetyl-3',5'-bis-O-(2,4-dichlorobenzyl)-β-D-ribofuranosyl>-6-chloro-9H-purin
CAS No.:168427-70-1
Molecular Formula:C₂₆H₂₁Cl₅N₄O₅
Molecular Weight:646.742
Hs Code.:

Synonyms:9-<2'-O-Acetyl-3',5'-bis-O-(2,4-dichlorobenzyl)-β-D-ribofuranosyl>-6-chloro-9H-purin

Suppliers and Price of 9-<2'-O-Acetyl-3',5'-bis-O-(2,4-dichlorobenzyl)-β-D-ribofuranosyl>-6-chloro-9H-purin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 9-<2'-O-Acetyl-3',5'-bis-O-(2,4-dichlorobenzyl)-β-D-ribofuranosyl>-6-chloro-9H-purin

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 9-<2'-O-Acetyl-3',5'-bis-O-(2,4-dichlorobenzyl)-β-D-ribofuranosyl>-6-chloro-9H-purin

There total 6 articles about 9-<2'-O-Acetyl-3',5'-bis-O-(2,4-dichlorobenzyl)-β-D-ribofuranosyl>-6-chloro-9H-purin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 168427-69-8
2-O-Acetyl-3',5'-bis-O-(2,4-dichlorobenzyl)inosin

: 168427-70-1
9-<2'-O-Acetyl-3',5'-bis-O-(2,4-dichlorobenzyl)-β-D-ribofuranosyl>-6-chloro-9H-purin

Guidance literature:: With thionyl chloride; In dichloromethane; N,N-dimethyl-formamide; at 55 ℃; for 5.5h;
DOI:10.1002/hlca.19950780219

Reference yield:

: 50-69-1
D-ribose

: 168427-70-1
9-<2'-O-Acetyl-3',5'-bis-O-(2,4-dichlorobenzyl)-β-D-ribofuranosyl>-6-chloro-9H-purin

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) cc. H₂SO₄, 2.) NaH / 1.) 4 deg C, 16 h, 2.) DMF, 40 deg C

2: 125.9 g / SnCl₄ / CH₂Cl₂ / 35 h / 3 °C

3: pyridine, 4-(dimethylamino)-pyridine / 17 h

4: 63 percent / BSA, TfOSiMe₃ / 1,2-dichloro-ethane / 7 h / 70 °C

5: 96 percent / SOCl₂ / dimethylformamide; CH₂Cl₂ / 5.5 h / 55 °C

With pyridine; benzenesulfonamide; dmap; thionyl chloride; trimethylsilyl trifluoromethanesulfonate; sulfuric acid; tin(IV) chloride; sodium hydride; In dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1002/hlca.19950780219

Reference yield:

: 94-99-5
2,4-Dichlorobenzyl chloride

: 168427-70-1
9-<2'-O-Acetyl-3',5'-bis-O-(2,4-dichlorobenzyl)-β-D-ribofuranosyl>-6-chloro-9H-purin

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) cc. H₂SO₄, 2.) NaH / 1.) 4 deg C, 16 h, 2.) DMF, 40 deg C

2: 125.9 g / SnCl₄ / CH₂Cl₂ / 35 h / 3 °C

3: pyridine, 4-(dimethylamino)-pyridine / 17 h

4: 63 percent / BSA, TfOSiMe₃ / 1,2-dichloro-ethane / 7 h / 70 °C

5: 96 percent / SOCl₂ / dimethylformamide; CH₂Cl₂ / 5.5 h / 55 °C

With pyridine; benzenesulfonamide; dmap; thionyl chloride; trimethylsilyl trifluoromethanesulfonate; sulfuric acid; tin(IV) chloride; sodium hydride; In dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1002/hlca.19950780219