N-benzyl-N-{3-[4-(2-tert-butylsulfamoyl-5-isobutyl-thiophen-3-yl)-benzyl]-4-oxo-2-propyl-3,4-dihydro-quinazolin-6-yl}-benzamide

Base Information

Chemical Name:N-benzyl-N-{3-[4-(2-tert-butylsulfamoyl-5-isobutyl-thiophen-3-yl)-benzyl]-4-oxo-2-propyl-3,4-dihydro-quinazolin-6-yl}-benzamide
CAS No.:678144-97-3
Molecular Formula:C₄₄H₄₈N₄O₄S₂
Molecular Weight:761.022
Hs Code.:

<i>N</i>-benzyl-<i>N</i>-{3-[4-(2-<i>tert</i>-butylsulfamoyl-5-isobutyl-thiophen-3-yl)-benzyl]-4-oxo-2-propyl-3,4-dihydro-quinazolin-6-yl}-benzamide

Synonyms:N-benzyl-N-{3-[4-(2-tert-butylsulfamoyl-5-isobutyl-thiophen-3-yl)-benzyl]-4-oxo-2-propyl-3,4-dihydro-quinazolin-6-yl}-benzamide

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Chemical Property of N-benzyl-N-{3-[4-(2-tert-butylsulfamoyl-5-isobutyl-thiophen-3-yl)-benzyl]-4-oxo-2-propyl-3,4-dihydro-quinazolin-6-yl}-benzamide

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Technology Process of N-benzyl-N-{3-[4-(2-tert-butylsulfamoyl-5-isobutyl-thiophen-3-yl)-benzyl]-4-oxo-2-propyl-3,4-dihydro-quinazolin-6-yl}-benzamide

There total 6 articles about N-benzyl-N-{3-[4-(2-tert-butylsulfamoyl-5-isobutyl-thiophen-3-yl)-benzyl]-4-oxo-2-propyl-3,4-dihydro-quinazolin-6-yl}-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 98-88-4
benzoyl chloride

: 678144-89-3
3-(4-{[6-(benzylamino)-4-oxo-2-propyl-3,4-dihydroquinazolin-3-yl]methyl}phenyl)-N-tert-butyl-5-isobutylthiophene-2-sulfonamide

: 678144-97-3
N-benzyl-N-{3-[4-(2-tert-butylsulfamoyl-5-isobutyl-thiophen-3-yl)-benzyl]-4-oxo-2-propyl-3,4-dihydro-quinazolin-6-yl}-benzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;
DOI:10.1021/jm031031i

Reference yield:

: 156483-24-8
3-(4-bromobenzyl)-6-nitro-2-propyl-3,4-dihydroquinazolin-4-one

: 678144-97-3
N-benzyl-N-{3-[4-(2-tert-butylsulfamoyl-5-isobutyl-thiophen-3-yl)-benzyl]-4-oxo-2-propyl-3,4-dihydro-quinazolin-6-yl}-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 82 percent / [Pd(Ph₃)4]; NaOH / ethanol; toluene; H₂O / 2 h / 100 °C

2.1: 92 percent / HCO₂NH₄ / Pd/C / methanol / 2.5 h

3.1: acetic acid / 1,2-dichloro-ethane / 0.5 h

3.2: 95 percent / NaB(OAc)3H / 1,2-dichloro-ethane

4.1: 93 percent / DIEA / CH₂Cl₂ / 20 °C

With sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonium formate; acetic acid; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; ethanol; dichloromethane; water; 1,2-dichloro-ethane; toluene; 1.1: Suzuki coupling;
DOI:10.1021/jm031031i

Reference yield:

: 163520-14-7
5-isobutyl-2 -(tert-butylaminosulfonyl)-3-thiopheneboronic acid

: 678144-97-3
N-benzyl-N-{3-[4-(2-tert-butylsulfamoyl-5-isobutyl-thiophen-3-yl)-benzyl]-4-oxo-2-propyl-3,4-dihydro-quinazolin-6-yl}-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 82 percent / [Pd(Ph₃)4]; NaOH / ethanol; toluene; H₂O / 2 h / 100 °C

2.1: 92 percent / HCO₂NH₄ / Pd/C / methanol / 2.5 h

3.1: acetic acid / 1,2-dichloro-ethane / 0.5 h

3.2: 95 percent / NaB(OAc)3H / 1,2-dichloro-ethane

4.1: 93 percent / DIEA / CH₂Cl₂ / 20 °C

With sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonium formate; acetic acid; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; ethanol; dichloromethane; water; 1,2-dichloro-ethane; toluene; 1.1: Suzuki coupling;
DOI:10.1021/jm031031i