6-chloro-N-diphenylmethyl-2-methyl-aureanindol-16-ene-21-oic acid

Base Information

• Chemical Name: 6-chloro-N-diphenylmethyl-2-methyl-aureanindol-16-ene-21-oic acid
• CAS No.: 1567367-30-9
• Molecular Formula: C₃₇H₄₀ClNO₂
• Molecular Weight: 566.183
• Mol file: 1567367-30-9.mol

Synonyms:6-chloro-N-diphenylmethyl-2-methyl-aureanindol-16-ene-21-oic acid

Chemical Property of 6-chloro-N-diphenylmethyl-2-methyl-aureanindol-16-ene-21-oic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-chloro-N-diphenylmethyl-2-methyl-aureanindol-16-ene-21-oic acid

There total 3 articles about 6-chloro-N-diphenylmethyl-2-methyl-aureanindol-16-ene-21-oic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methyl 6-chloro-N-diphenylmethyl-2-methyl-aureanindol-16-ene-21-oate (1567367-29-6) → 6-chloro-N-diphenylmethyl-2-methyl-aureanindol-16-ene-21-oic acid (1567367-30-9)

Guidance literature:

With potassium tert-butylate; In tert-butyl alcohol; at 90 ℃; for 16h;

DOI:10.1016/j.ejmech.2013.12.012

Reference yield:

methyl 13-oxo-14,15-dinor-1(10)-ent-halimen-18-oate (67988-00-5) → 6-chloro-N-diphenylmethyl-2-methyl-aureanindol-16-ene-21-oic acid (1567367-30-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydroxide / water / 0.17 h / Inert atmosphere

1.2: 23 h / 20 - 130 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / Inert atmosphere; Cooling with ice

2.2: 1.25 h / 20 °C / Inert atmosphere

3.1: potassium tert-butylate / tert-butyl alcohol / 16 h / 90 °C

With potassium tert-butylate; sodium hydride; sodium hydroxide; In water; N,N-dimethyl-formamide; mineral oil; tert-butyl alcohol; 1.2: |Fischer Indole Synthesis;

DOI:10.1016/j.ejmech.2013.12.012

Reference yield:

methyl 6-chloro-2-methyl-aureanindol-16-ene-21-oate (1567367-20-7) + Bromodiphenylmethane (776-74-9) → 6-chloro-N-diphenylmethyl-2-methyl-aureanindol-16-ene-21-oic acid (1567367-30-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / Inert atmosphere; Cooling with ice

1.2: 1.25 h / 20 °C / Inert atmosphere

2.1: potassium tert-butylate / tert-butyl alcohol / 16 h / 90 °C

With potassium tert-butylate; sodium hydride; In N,N-dimethyl-formamide; mineral oil; tert-butyl alcohol;

DOI:10.1016/j.ejmech.2013.12.012

upstream raw materials:

methyl 6-chloro-2-methyl-aureanindol-16-ene-21-oate

Bromodiphenylmethane

methyl 13-oxo-14,15-dinor-1⁽¹⁰⁾-ent-halimen-18-oate

methyl 6-chloro-N-diphenylmethyl-2-methyl-aureanindol-16-ene-21-oate