{3-amino-4-[(3-octylphenyl)(4-methylphenylsulfonyl)amino]butyl}phosphonic acid diethyl ester

Base Information

Chemical Name:{3-amino-4-[(3-octylphenyl)(4-methylphenylsulfonyl)amino]butyl}phosphonic acid diethyl ester
CAS No.:925707-02-4
Molecular Formula:C₂₉H₄₇N₂O₅PS
Molecular Weight:566.742
Hs Code.:

Synonyms:{3-amino-4-[(3-octylphenyl)(4-methylphenylsulfonyl)amino]butyl}phosphonic acid diethyl ester

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Chemical Property of {3-amino-4-[(3-octylphenyl)(4-methylphenylsulfonyl)amino]butyl}phosphonic acid diethyl ester

Chemical Property:

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Technology Process of {3-amino-4-[(3-octylphenyl)(4-methylphenylsulfonyl)amino]butyl}phosphonic acid diethyl ester

There total 7 articles about {3-amino-4-[(3-octylphenyl)(4-methylphenylsulfonyl)amino]butyl}phosphonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 925707-01-3
{3-azido-4-[(3-octylphenyl)(4-methylphenylsulfonyl)amino]butyl}phosphonic acid diethyl ester

: 925707-02-4
{3-amino-4-[(3-octylphenyl)(4-methylphenylsulfonyl)amino]butyl}phosphonic acid diethyl ester

Guidance literature:: With hydrogenchloride; hydrogen; palladium dihydroxide; In methanol; for 1h;
DOI:10.1016/j.bmc.2006.10.060

Reference yield:

: 118198-99-5
m-octylaniline

: 925707-02-4
{3-amino-4-[(3-octylphenyl)(4-methylphenylsulfonyl)amino]butyl}phosphonic acid diethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 97 percent / pyridine / 1 h / 0 - 20 °C

2.1: 69 percent / PPh₃; diisopropyl azodicarboxylate / tetrahydrofuran / 24 h / 0 - 20 °C

3.1: n-BuLi / tetrahydrofuran; hexane / 0.25 h / -78 °C

3.2: 97 percent / BF₃*Et₂O / tetrahydrofuran; hexane / 2 h / -78 °C

4.1: 85 percent / diphenylphosphoryl azide; diisopropyl azodicarboxylate; polymer-bound PPh₃ / CH₂Cl₂ / 20 h / 0 - 20 °C

5.1: 100 percent / H₂; HCl / Pd(OH)2 / methanol / 1 h

With pyridine; hydrogenchloride; n-butyllithium; di-isopropyl azodicarboxylate; polymer-bound PPh₃; diphenylphosphoranyl azide; hydrogen; triphenylphosphine; palladium dihydroxide; In tetrahydrofuran; methanol; hexane; dichloromethane; 2.1: Mitsunobu reaction;
DOI:10.1016/j.bmc.2006.10.060

Reference yield:

: 925706-99-6
4-methyl-N-(3-octylphenyl)-N-oxiranylmethylbenzenesulfonamide

: 925707-02-4
{3-amino-4-[(3-octylphenyl)(4-methylphenylsulfonyl)amino]butyl}phosphonic acid diethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 0.25 h / -78 °C

1.2: 97 percent / BF₃*Et₂O / tetrahydrofuran; hexane / 2 h / -78 °C

2.1: 85 percent / diphenylphosphoryl azide; diisopropyl azodicarboxylate; polymer-bound PPh₃ / CH₂Cl₂ / 20 h / 0 - 20 °C

3.1: 100 percent / H₂; HCl / Pd(OH)2 / methanol / 1 h

With hydrogenchloride; n-butyllithium; di-isopropyl azodicarboxylate; polymer-bound PPh₃; diphenylphosphoranyl azide; hydrogen; palladium dihydroxide; In tetrahydrofuran; methanol; hexane; dichloromethane;
DOI:10.1016/j.bmc.2006.10.060