{3-azido-4-[(3-octylphenyl)(4-methylphenylsulfonyl)amino]butyl}phosphonic acid diethyl ester

Base Information

• Chemical Name: {3-azido-4-[(3-octylphenyl)(4-methylphenylsulfonyl)amino]butyl}phosphonic acid diethyl ester
• CAS No.: 925707-01-3
• Molecular Formula: C₂₉H₄₅N₄O₅PS
• Molecular Weight: 592.74
• Mol file: 925707-01-3.mol

Synonyms:{3-azido-4-[(3-octylphenyl)(4-methylphenylsulfonyl)amino]butyl}phosphonic acid diethyl ester

Chemical Property of {3-azido-4-[(3-octylphenyl)(4-methylphenylsulfonyl)amino]butyl}phosphonic acid diethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {3-azido-4-[(3-octylphenyl)(4-methylphenylsulfonyl)amino]butyl}phosphonic acid diethyl ester

There total 6 articles about {3-azido-4-[(3-octylphenyl)(4-methylphenylsulfonyl)amino]butyl}phosphonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

{3-hydroxy-4-[(3-octylphenyl)(4-methylphenylsulfonyl)amino]butyl}phosphonic acid diethyl ester (925707-00-2) → {3-azido-4-[(3-octylphenyl)(4-methylphenylsulfonyl)amino]butyl}phosphonic acid diethyl ester (925707-01-3)

Guidance literature:

With di-isopropyl azodicarboxylate; polymer-bound PPh₃; diphenylphosphoranyl azide; In dichloromethane; at 0 - 20 ℃; for 20h;

DOI:10.1016/j.bmc.2006.10.060

Reference yield:

m-octylaniline (118198-99-5) → {3-azido-4-[(3-octylphenyl)(4-methylphenylsulfonyl)amino]butyl}phosphonic acid diethyl ester (925707-01-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 97 percent / pyridine / 1 h / 0 - 20 °C

2.1: 69 percent / PPh₃; diisopropyl azodicarboxylate / tetrahydrofuran / 24 h / 0 - 20 °C

3.1: n-BuLi / tetrahydrofuran; hexane / 0.25 h / -78 °C

3.2: 97 percent / BF₃*Et₂O / tetrahydrofuran; hexane / 2 h / -78 °C

4.1: 85 percent / diphenylphosphoryl azide; diisopropyl azodicarboxylate; polymer-bound PPh₃ / CH₂Cl₂ / 20 h / 0 - 20 °C

With pyridine; n-butyllithium; di-isopropyl azodicarboxylate; polymer-bound PPh₃; diphenylphosphoranyl azide; triphenylphosphine; In tetrahydrofuran; hexane; dichloromethane; 2.1: Mitsunobu reaction;

DOI:10.1016/j.bmc.2006.10.060

Reference yield:

4-methyl-N-(3-octylphenyl)-N-oxiranylmethylbenzenesulfonamide (925706-99-6) → {3-azido-4-[(3-octylphenyl)(4-methylphenylsulfonyl)amino]butyl}phosphonic acid diethyl ester (925707-01-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 0.25 h / -78 °C

1.2: 97 percent / BF₃*Et₂O / tetrahydrofuran; hexane / 2 h / -78 °C

2.1: 85 percent / diphenylphosphoryl azide; diisopropyl azodicarboxylate; polymer-bound PPh₃ / CH₂Cl₂ / 20 h / 0 - 20 °C

With n-butyllithium; di-isopropyl azodicarboxylate; polymer-bound PPh₃; diphenylphosphoranyl azide; In tetrahydrofuran; hexane; dichloromethane;

DOI:10.1016/j.bmc.2006.10.060

upstream raw materials:

{3-hydroxy-4-[(3-octylphenyl)(4-methylphenylsulfonyl)amino]butyl}phosphonic acid diethyl ester

m-octylaniline

4-methyl-N-(3-octylphenyl)-N-oxiranylmethylbenzenesulfonamide

Diethyl methylphosphonate

Downstream raw materials:

{3-amino-4-[(3-octylphenyl)(4-methylphenylsulfonyl)amino]butyl}phosphonic acid diethyl ester

[3-amino-4-(3-octylphenylamino)butyl]phosphonic acid diethyl ester