(S)-(+)-2-(N-diphenylphosphinyl)amino-3-methylbutyrophenone

Base Information

Chemical Name:(S)-(+)-2-(N-diphenylphosphinyl)amino-3-methylbutyrophenone
CAS No.:189823-48-1
Molecular Formula:C₂₃H₂₄NO₂P
Molecular Weight:377.423
Hs Code.:

Synonyms:(S)-(+)-2-(N-diphenylphosphinyl)amino-3-methylbutyrophenone

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Chemical Property of (S)-(+)-2-(N-diphenylphosphinyl)amino-3-methylbutyrophenone

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Technology Process of (S)-(+)-2-(N-diphenylphosphinyl)amino-3-methylbutyrophenone

There total 9 articles about (S)-(+)-2-(N-diphenylphosphinyl)amino-3-methylbutyrophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 189823-51-6
C₂₃H₂₆NO₂P

: 189823-48-1
(S)-(+)-2-(N-diphenylphosphinyl)amino-3-methylbutyrophenone

Guidance literature:: With tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide; In dichloromethane; for 2h; Ambient temperature;
DOI:10.1016/S0040-4020(98)00474-8

Reference yield:

: 13734-41-3
t-Boc-L-valine

: 189823-48-1
(S)-(+)-2-(N-diphenylphosphinyl)amino-3-methylbutyrophenone

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine, pivaloyl chloride / CH₂Cl₂ / 1 h / 0 °C

2: hydrochloric acid / methanol / 4 h / 0 °C

3: 1.31 g / triethylamine / CH₂Cl₂ / 18 h / Ambient temperature

4: 44 percent / diethyl ether; cyclohexane / 4 h / 0 °C

With hydrogenchloride; pivaloyl chloride; triethylamine; In methanol; diethyl ether; dichloromethane; cyclohexane;
DOI:10.1016/S0040-4020(98)00474-8

Reference yield:

: 2026-48-4,473-75-6
(S)-valinol

: 189823-48-1
(S)-(+)-2-(N-diphenylphosphinyl)amino-3-methylbutyrophenone

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / triethylamine / CH₂Cl₂ / 16 h / Ambient temperature

2: 92 percent / Dess-Martin periodinate / CH₂Cl₂ / 2 h / Ambient temperature

3: tetrahydrofuran; diethyl ether / 0.5 h / -78 °C

4: 93 percent / tetrapropylammonium perruthenate, N-methylmorpholine N-oxide / CH₂Cl₂ / 2 h / Ambient temperature

With tetrapropylammonium perruthennate; Dess-Martin periodane; 4-methylmorpholine N-oxide; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1016/S0040-4020(98)00474-8