2'-TOSYLADENOSINE

Base Information

• Chemical Name: 2'-TOSYLADENOSINE
• CAS No.: 42776-78-3
• Molecular Formula: C17H19 N5 O6 S
• Molecular Weight: 421.434
• Mol file: 42776-78-3.mol

Synonyms:Adenosine,2'-p-toluenesulfonate (6CI); 2'-O-Tosyladenosine;2'-O-p-Toluenesulfonyladenosine; 2'-p-Tosyladenosine

Chemical Property of 2'-TOSYLADENOSINE

Chemical Property:

• Melting Point: 222-223 °C
• Boiling Point: 772.1±70.0 °C(Predicted)
• PKA: 12.61±0.70(Predicted)
• PSA: 182.06000
• Density: 1.75±0.1 g/cm3(Predicted)
• LogP: 0.79200
• Storage Temp.: -20°C

Purity/Quality:

97% ^*data from raw suppliers

2'-TOSYLADENOSINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2'-TOSYLADENOSINE

There total 22 articles about 2'-TOSYLADENOSINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

p-toluenesulfonyl chloride (98-59-9) + adenosine (58-61-7) → 2'-O-tosyladenosine (42776-78-3)

Guidance literature:

With di(n-butyl)tin oxide; n-C₆H₅CH₂(C₂H₅)3N(+)*Cl(-); In dichloromethane; for 24h; Ambient temperature;

DOI:10.1055/s-1987-28193

Reference yield: 89.2%

2',3'-O-(dibutylstannylene)adenosine (42822-80-0) + p-toluenesulfonyl chloride (98-59-9) → 2'-O-tosyladenosine (42776-78-3)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃;

Reference yield: 85.5%

O3',O5'-diacetyl-O2'-(toluene-4-sulfonyl)-adenosine → 2'-O-tosyladenosine (42776-78-3)

Guidance literature:

With azobisisobutyronitrile; tri-n-butyl-tin hydride; In toluene; at 75 - 100 ℃; for 54h;

upstream raw materials:

3',5'-di-O-toluoyl 2'-tosyl adenosine

2',3'-O-(dibutylstannylene)adenosine

p-toluenesulfonyl chloride

adenosine

Downstream raw materials:

N⁶,O⁵'-bis(4,4'-dimethoxytrityl)-2'-O-tosyladenosine

N⁶,O⁵'-ditrityl-2'-O-tosyladenosine

2'-O-(p-toluenesulfonyl)-5'-O-(triphenylmethyl)adenosine

5'-O-(tert-butyldimethylsilyl)-2'-O-(p-tolylsulfonyl)adenosine