O-HYDROXY-BETA-PHENYL PROPIOPHENONE

Base Information

• Chemical Name: O-HYDROXY-BETA-PHENYL PROPIOPHENONE
• CAS No.: 42772-82-7
• Molecular Formula: C15H14 O2
• Molecular Weight: 226.275
• Hs Code.: 2914501900
• Mol file: 42772-82-7.mol

Synonyms:1-(2-Hydroxyphenyl)-3-phenyl-1-propanone

Chemical Property of O-HYDROXY-BETA-PHENYL PROPIOPHENONE

Chemical Property:

• Boiling Point: 381.1°Cat760mmHg
• Flash Point: 162.7°C
• PSA: 37.30000
• Density: 1.15g/cm³
• LogP: 3.20770

Purity/Quality:

95%,98%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of O-HYDROXY-BETA-PHENYL PROPIOPHENONE

There total 4 articles about O-HYDROXY-BETA-PHENYL PROPIOPHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + salicylaldehyde (90-02-8) → 2'-hydroxy-3-phenylpropiophenone (3516-95-8) + 1-(2-Hydroxyphenyl)-2-phenylpropan-1-one (42772-82-7)

Guidance literature:

With potassium phosphate; chloro(1,5-cyclooctadiene)rhodium(I) dimer; (11aR)-(+)-10,11,12,13-tetrahydrodiindeno[7,1-de:1', 7'-fg][1,3,2]dioxaphosphocin-5-bis[(R)-1-phenylethyl]amine; In 1,2-dichloro-ethane; at 70 ℃; for 36h; Overall yield = 98 %; Inert atmosphere;

DOI:10.1021/ja305593y

Reference yield: 48.0%

isoflavone (574-12-9) → 1-(2-Hydroxyphenyl)-2-phenylpropan-1-one (42772-82-7) + 1-(2-Hydroxyphenyl)-2-phenylprop-2-en-1-ol (1481-89-6)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 0.25h; Heating;

DOI:10.1039/a904946k

Reference yield:

α-methylbenzeneacetic acid phenyl ester (97479-89-5) → 2-(1-phenylethyl)phenol (4237-44-9) + 1-(4-hydroxy-phenyl)-2-phenyl-propan-1-one (724-87-8) + 1-(2-Hydroxyphenyl)-2-phenylpropan-1-one (42772-82-7) + α-phenoxyethylbenzene (4747-11-9)

Guidance literature:

In hexane; at 22 ℃; Further Variations:; Solvents; Product distribution; Irradiation;

DOI:10.1021/jo001455+

upstream raw materials:

isoflavone

α-methylbenzeneacetic acid phenyl ester

styrene

salicylaldehyde

Downstream raw materials:

1-(2-hydroxyphenyl)-2-phenyl-2-propen-1-one

isoflavone