(3S,4R,5S)-2,2-diethyl 3,4-dimethyl 5-(4-bromophenyl)pyrrolidine-2,2,3,4-tetracarboxylate

Base Information

Chemical Name:(3S,4R,5S)-2,2-diethyl 3,4-dimethyl 5-(4-bromophenyl)pyrrolidine-2,2,3,4-tetracarboxylate
CAS No.:1022349-75-2
Molecular Formula:C₂₀H₂₄BrNO₈
Molecular Weight:486.316
Hs Code.:

Synonyms:(3S,4R,5S)-2,2-diethyl 3,4-dimethyl 5-(4-bromophenyl)pyrrolidine-2,2,3,4-tetracarboxylate

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Chemical Property of (3S,4R,5S)-2,2-diethyl 3,4-dimethyl 5-(4-bromophenyl)pyrrolidine-2,2,3,4-tetracarboxylate

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Technology Process of (3S,4R,5S)-2,2-diethyl 3,4-dimethyl 5-(4-bromophenyl)pyrrolidine-2,2,3,4-tetracarboxylate

There total 2 articles about (3S,4R,5S)-2,2-diethyl 3,4-dimethyl 5-(4-bromophenyl)pyrrolidine-2,2,3,4-tetracarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 6829-40-9
aminomalonic acid diethyl ester

: 624-48-6
dimethyl cis-but-2-ene-1,4-dioate

: 1122-91-4
4-bromo-benzaldehyde

: 1022349-75-2
(3S,4R,5S)-2,2-diethyl 3,4-dimethyl 5-(4-bromophenyl)pyrrolidine-2,2,3,4-tetracarboxylate

Guidance literature:: With 3 A molecular sieve; [(R)-1,1'-BINOL-2,2'-phosphate-3-CH₂]2O; In dichloromethane; at 25 ℃;
DOI:10.1021/ja801034e

Reference yield: 73.0%

: 3959-07-7
4-Bromobenzylamine

: 23055-10-9
1,4-dimethyl but-2-enedioate

: 609-09-6
Diethyl ketomalonate

: 1022349-75-2
(3S,4R,5S)-2,2-diethyl 3,4-dimethyl 5-(4-bromophenyl)pyrrolidine-2,2,3,4-tetracarboxylate

Guidance literature:: 4-Bromobenzylamine; Diethyl ketomalonate; With C₄₂H₂₈O₉P₂; In dichloromethane; at 25 ℃; for 4h; Molecular sieve;

1,4-dimethyl but-2-enedioate; In dichloromethane; at 50 ℃; for 192h; enantioselective reaction; Molecular sieve;
DOI:10.1021/ol400983j