Methanesulfonic acid (1R,2R,3S,4S)-4-benzyloxycarbonylamino-2,3-bis-methoxymethoxy-1-pent-4-enyl-octyl ester

Base Information

Chemical Name:Methanesulfonic acid (1R,2R,3S,4S)-4-benzyloxycarbonylamino-2,3-bis-methoxymethoxy-1-pent-4-enyl-octyl ester
CAS No.:118014-69-0
Molecular Formula:C₂₆H₄₃NO₉S
Molecular Weight:545.695
Hs Code.:

Synonyms:Methanesulfonic acid (1R,2R,3S,4S)-4-benzyloxycarbonylamino-2,3-bis-methoxymethoxy-1-pent-4-enyl-octyl ester

Suppliers and Price of Methanesulfonic acid (1R,2R,3S,4S)-4-benzyloxycarbonylamino-2,3-bis-methoxymethoxy-1-pent-4-enyl-octyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of Methanesulfonic acid (1R,2R,3S,4S)-4-benzyloxycarbonylamino-2,3-bis-methoxymethoxy-1-pent-4-enyl-octyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Methanesulfonic acid (1R,2R,3S,4S)-4-benzyloxycarbonylamino-2,3-bis-methoxymethoxy-1-pent-4-enyl-octyl ester

There total 22 articles about Methanesulfonic acid (1R,2R,3S,4S)-4-benzyloxycarbonylamino-2,3-bis-methoxymethoxy-1-pent-4-enyl-octyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 117941-00-1
(2S,3R)-1-(Benzyloxy)-2,3-bis<(methoxymethyl)oxy>octan-4-one

: 118014-69-0
Methanesulfonic acid (1R,2R,3S,4S)-4-benzyloxycarbonylamino-2,3-bis-methoxymethoxy-1-pent-4-enyl-octyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: 75 percent / 1 M LiBH(sec-Bu)3 / tetrahydrofuran / 1 h / -78 °C

2: 51 percent / triphenyl phosphine, diethyl azodicarboxylate / tetrahydrofuran / 14 h / Ambient temperature

3: 76 percent / H₂ / 10percent Pd/C / methanol / 3 h

4: 86 percent / oxalyl chloride, dimethyl sulfoxide / CH₂Cl₂ / 1 h / -78 °C

5: 1.) Mg / 1.) THF, 2.) THF, -78 deg C, 30 min

6: hydrazine hydrate / ethanol / 2 h / Heating

7: aq. Na₂CO₃ / CH₂Cl₂ / 0.08 h / 0 °C

8: 80 percent / oxalyl chloride, dimethyl sulfoxide / CH₂Cl₂ / 1 h / -78 °C

9: 0.14 M Zn(BH₄)2 / diethyl ether / 0.75 h / 0 °C

10: triethylamine / CH₂Cl₂ / 0.17 h / 0 °C

With zinc(II) tetrahydroborate; oxalyl dichloride; hydrogen; L-Selectride; sodium carbonate; hydrazine hydrate; magnesium; dimethyl sulfoxide; triethylamine; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane;
DOI:10.1021/ja00186a038

Reference yield:

: 99878-63-4
4-O-benzyl-2,3-O-bis(methoxymethyl)-L-threose

: 118014-69-0
Methanesulfonic acid (1R,2R,3S,4S)-4-benzyloxycarbonylamino-2,3-bis-methoxymethoxy-1-pent-4-enyl-octyl ester

Guidance literature:: Multi-step reaction with 12 steps

1: 1.) Mg / 1.) Et₂O, 2.) Et₂O, room temp., 14 h

2: 95 percent / oxalyl chloride, dimethyl sulfoxide / CH₂Cl₂ / 1 h / -78 °C

3: 75 percent / 1 M LiBH(sec-Bu)3 / tetrahydrofuran / 1 h / -78 °C

4: 51 percent / triphenyl phosphine, diethyl azodicarboxylate / tetrahydrofuran / 14 h / Ambient temperature

5: 76 percent / H₂ / 10percent Pd/C / methanol / 3 h

6: 86 percent / oxalyl chloride, dimethyl sulfoxide / CH₂Cl₂ / 1 h / -78 °C

7: 1.) Mg / 1.) THF, 2.) THF, -78 deg C, 30 min

8: hydrazine hydrate / ethanol / 2 h / Heating

9: aq. Na₂CO₃ / CH₂Cl₂ / 0.08 h / 0 °C

10: 80 percent / oxalyl chloride, dimethyl sulfoxide / CH₂Cl₂ / 1 h / -78 °C

11: 0.14 M Zn(BH₄)2 / diethyl ether / 0.75 h / 0 °C

12: triethylamine / CH₂Cl₂ / 0.17 h / 0 °C

With zinc(II) tetrahydroborate; oxalyl dichloride; hydrogen; L-Selectride; sodium carbonate; hydrazine hydrate; magnesium; dimethyl sulfoxide; triethylamine; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane;
DOI:10.1021/ja00186a038

Reference yield:

: 117941-01-2,118014-58-7
(2S,3S)-1-Benzyloxy-2,3-bis-methoxymethoxy-octan-4-ol

: 118014-69-0
Methanesulfonic acid (1R,2R,3S,4S)-4-benzyloxycarbonylamino-2,3-bis-methoxymethoxy-1-pent-4-enyl-octyl ester

Guidance literature:: Multi-step reaction with 11 steps

1: 95 percent / oxalyl chloride, dimethyl sulfoxide / CH₂Cl₂ / 1 h / -78 °C

2: 75 percent / 1 M LiBH(sec-Bu)3 / tetrahydrofuran / 1 h / -78 °C

3: 51 percent / triphenyl phosphine, diethyl azodicarboxylate / tetrahydrofuran / 14 h / Ambient temperature

4: 76 percent / H₂ / 10percent Pd/C / methanol / 3 h

5: 86 percent / oxalyl chloride, dimethyl sulfoxide / CH₂Cl₂ / 1 h / -78 °C

6: 1.) Mg / 1.) THF, 2.) THF, -78 deg C, 30 min

7: hydrazine hydrate / ethanol / 2 h / Heating

8: aq. Na₂CO₃ / CH₂Cl₂ / 0.08 h / 0 °C

9: 80 percent / oxalyl chloride, dimethyl sulfoxide / CH₂Cl₂ / 1 h / -78 °C

10: 0.14 M Zn(BH₄)2 / diethyl ether / 0.75 h / 0 °C

11: triethylamine / CH₂Cl₂ / 0.17 h / 0 °C

With zinc(II) tetrahydroborate; oxalyl dichloride; hydrogen; L-Selectride; sodium carbonate; hydrazine hydrate; magnesium; dimethyl sulfoxide; triethylamine; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane;
DOI:10.1021/ja00186a038