(4S,5S)-ethyl 5-[N-(4-methoxyphenyl)-N-methylamino]-4-methyl-5-phenylpentanoate

Base Information

Chemical Name:(4S,5S)-ethyl 5-[N-(4-methoxyphenyl)-N-methylamino]-4-methyl-5-phenylpentanoate
CAS No.:1536290-18-2
Molecular Formula:C₂₂H₂₉NO₃
Molecular Weight:355.477
Hs Code.:

Synonyms:(4S,5S)-ethyl 5-[N-(4-methoxyphenyl)-N-methylamino]-4-methyl-5-phenylpentanoate

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Chemical Property of (4S,5S)-ethyl 5-[N-(4-methoxyphenyl)-N-methylamino]-4-methyl-5-phenylpentanoate

Chemical Property:

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Technology Process of (4S,5S)-ethyl 5-[N-(4-methoxyphenyl)-N-methylamino]-4-methyl-5-phenylpentanoate

There total 8 articles about (4S,5S)-ethyl 5-[N-(4-methoxyphenyl)-N-methylamino]-4-methyl-5-phenylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1536290-17-1
(4S,5S,E)-ethyl 5-[N-(4-methoxyphenyl)-N-methylamino]-4-methyl-5-phenylpent-2-enoate

: 1536290-18-2
(4S,5S)-ethyl 5-[N-(4-methoxyphenyl)-N-methylamino]-4-methyl-5-phenylpentanoate

Guidance literature:: With platinum(IV) oxide; hydrogen; In ethyl acetate; at 20 ℃; for 1h;
DOI:10.1039/c3ra45110k

Reference yield:

: (4S,5R)-3-(4-methoxyphenyl)-5-methyl-4-phenyl-1,3-oxazinane

: 1536290-18-2
(4S,5S)-ethyl 5-[N-(4-methoxyphenyl)-N-methylamino]-4-methyl-5-phenylpentanoate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium tetrahydroborate; trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

2: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / Reflux

3: dichloromethane / 5 h / 20 °C

4: platinum(IV) oxide; hydrogen / ethyl acetate / 1 h / 20 °C

With platinum(IV) oxide; sodium tetrahydroborate; hydrogen; trifluoroacetic acid; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In dichloromethane; ethyl acetate; 3: |Wittig Olefination;
DOI:10.1039/c3ra45110k

Reference yield:

: 1536290-13-7
(2R,3S)-3-[N-(4-methoxyphenyl)-N-methylamino]-2-methyl-3-phenylpropan-1-ol

: 1536290-18-2
(4S,5S)-ethyl 5-[N-(4-methoxyphenyl)-N-methylamino]-4-methyl-5-phenylpentanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / Reflux

2: dichloromethane / 5 h / 20 °C

3: platinum(IV) oxide; hydrogen / ethyl acetate / 1 h / 20 °C

With platinum(IV) oxide; hydrogen; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In dichloromethane; ethyl acetate; 2: |Wittig Olefination;
DOI:10.1039/c3ra45110k