(2R,3S)-3-[N-(4-methoxyphenyl)-N-methylamino]-2-methyl-3-phenylpropan-1-ol

Base Information

Chemical Name:(2R,3S)-3-[N-(4-methoxyphenyl)-N-methylamino]-2-methyl-3-phenylpropan-1-ol
CAS No.:1536290-13-7
Molecular Formula:C₁₈H₂₃NO₂
Molecular Weight:285.386
Hs Code.:

Synonyms:(2R,3S)-3-[N-(4-methoxyphenyl)-N-methylamino]-2-methyl-3-phenylpropan-1-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3S)-3-[N-(4-methoxyphenyl)-N-methylamino]-2-methyl-3-phenylpropan-1-ol

Chemical Property:

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Technology Process of (2R,3S)-3-[N-(4-methoxyphenyl)-N-methylamino]-2-methyl-3-phenylpropan-1-ol

There total 5 articles about (2R,3S)-3-[N-(4-methoxyphenyl)-N-methylamino]-2-methyl-3-phenylpropan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: (4S,5R)-3-(4-methoxyphenyl)-5-methyl-4-phenyl-1,3-oxazinane

: 1536290-13-7
(2R,3S)-3-[N-(4-methoxyphenyl)-N-methylamino]-2-methyl-3-phenylpropan-1-ol

Guidance literature:: With sodium tetrahydroborate; trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 2h;
DOI:10.1039/c3ra45110k

Reference yield:

: (2R,3S)-3-(4-methoxyphenylamino)-2-methyl-3-phenylpropanoic acid

: 1536290-13-7
(2R,3S)-3-[N-(4-methoxyphenyl)-N-methylamino]-2-methyl-3-phenylpropan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: dimethylsulfide borane complex / tetrahydrofuran / 4 h / 20 °C

2: acetonitrile / 2 h / 20 °C

3: sodium tetrahydroborate; trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

With sodium tetrahydroborate; dimethylsulfide borane complex; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1039/c3ra45110k

Reference yield:

: 334708-40-6
[2R,3S,1'S,2'S]-(+)-3-(4-methoxy-phenyl-amino)-N,2-dimethyl-3-phenyl-N-(2'-phenyl-2'-hydroxy-1'-methyl-ethyl)-propanamide

: 1536290-13-7
(2R,3S)-3-[N-(4-methoxyphenyl)-N-methylamino]-2-methyl-3-phenylpropan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: sulfuric acid / 1,4-dioxane / 6 h / 0 °C / Reflux

2: dimethylsulfide borane complex / tetrahydrofuran / 4 h / 20 °C

3: acetonitrile / 2 h / 20 °C

4: sodium tetrahydroborate; trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

With sodium tetrahydroborate; dimethylsulfide borane complex; sulfuric acid; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; acetonitrile;
DOI:10.1039/c3ra45110k