(Z)-(3-{2,6-dibromo-4-[4-oxo-2-thioxo-thiazolidin-(5Z)-ylidenemethyl]-phenoxy}-propyl)-carbamic acid benzyl ester

Base Information

• Chemical Name: (Z)-(3-{2,6-dibromo-4-[4-oxo-2-thioxo-thiazolidin-(5Z)-ylidenemethyl]-phenoxy}-propyl)-carbamic acid benzyl ester
• CAS No.: 1415814-09-3
• Molecular Formula: C₂₁H₁₈Br₂N₂O₄S₂
• Molecular Weight: 586.325
• Mol file: 1415814-09-3.mol

Synonyms:(Z)-(3-{2,6-dibromo-4-[4-oxo-2-thioxo-thiazolidin-(5Z)-ylidenemethyl]-phenoxy}-propyl)-carbamic acid benzyl ester

Chemical Property of (Z)-(3-{2,6-dibromo-4-[4-oxo-2-thioxo-thiazolidin-(5Z)-ylidenemethyl]-phenoxy}-propyl)-carbamic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-(3-{2,6-dibromo-4-[4-oxo-2-thioxo-thiazolidin-(5Z)-ylidenemethyl]-phenoxy}-propyl)-carbamic acid benzyl ester

There total 1 articles about (Z)-(3-{2,6-dibromo-4-[4-oxo-2-thioxo-thiazolidin-(5Z)-ylidenemethyl]-phenoxy}-propyl)-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

benzyl [3-(2,6-dibromo-4-formylphenoxy)propyl]carbamate (882687-07-2) + 2-thioxo-4-thiazolidinone (141-84-4) → (Z)-(3-{2,6-dibromo-4-[4-oxo-2-thioxo-thiazolidin-(5Z)-ylidenemethyl]-phenoxy}-propyl)-carbamic acid benzyl ester (1415814-09-3)

Guidance literature:

With ammonium acetate; In toluene; at 90 - 100 ℃; Inert atmosphere;

DOI:10.1021/ol303057a

Reference yield:

(Z)-(3-{2,6-dibromo-4-[4-oxo-2-thioxo-thiazolidin-(5Z)-ylidenemethyl]-phenoxy}-propyl)-carbamic acid benzyl ester (1415814-09-3) → C20H19Br2NO5S

Guidance literature:

With sodium hydroxide; In water; at 80 - 90 ℃; Inert atmosphere;

DOI:10.1021/ol303057a

Reference yield:

(Z)-(3-{2,6-dibromo-4-[4-oxo-2-thioxo-thiazolidin-(5Z)-ylidenemethyl]-phenoxy}-propyl)-carbamic acid benzyl ester (1415814-09-3) → (Z)-3-(4-(3-(benzyloxycarbonylamino)propoxy)-3,5-dibromophenyl)-2-(benzyloxyimino)propanoic acid

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / water / 80 - 90 °C / Inert atmosphere

2: sodium ethanolate / ethanol / 70 °C / Inert atmosphere

With sodium ethanolate; sodium hydroxide; In ethanol; water;

DOI:10.1021/ol303057a

upstream raw materials:

benzyl [3-(2,6-dibromo-4-formylphenoxy)propyl]carbamate

2-thioxo-4-thiazolidinone