(S,S)-tert-butyl bis(4-<2,3-di(tert-butoxycarbonylamino)propyl>phenyl)phosphinate

Base Information

Chemical Name:(S,S)-tert-butyl bis(4-<2,3-di(tert-butoxycarbonylamino)propyl>phenyl)phosphinate
CAS No.:223111-68-0
Molecular Formula:C₄₂H₆₇N₄O₁₀P
Molecular Weight:818.989
Hs Code.:

Synonyms:(S,S)-tert-butyl bis(4-<2,3-di(tert-butoxycarbonylamino)propyl>phenyl)phosphinate

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Chemical Property of (S,S)-tert-butyl bis(4-<2,3-di(tert-butoxycarbonylamino)propyl>phenyl)phosphinate

Chemical Property:

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Technology Process of (S,S)-tert-butyl bis(4-<2,3-di(tert-butoxycarbonylamino)propyl>phenyl)phosphinate

There total 5 articles about (S,S)-tert-butyl bis(4-<2,3-di(tert-butoxycarbonylamino)propyl>phenyl)phosphinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 174809-61-1
(S)-N,N'-di(tert-butoxycarbonyl)-1,2-diamino-(4-iodophenyl)propane

: 174809-63-3
tert-butyl (4-((2S)-di(tert-butoxycarbonylamino)propyl)phenyl)phosphinate

: 223111-68-0
(S,S)-tert-butyl bis(4-<2,3-di(tert-butoxycarbonylamino)propyl>phenyl)phosphinate

Guidance literature:: With tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; triethylamine; In acetonitrile; at 90 ℃; for 14h;
DOI:10.1021/jo9804590

Reference yield:

: 174809-61-1
(S)-N,N'-di(tert-butoxycarbonyl)-1,2-diamino-(4-iodophenyl)propane

: 174809-63-3
tert-butyl (4-((2S)-di(tert-butoxycarbonylamino)propyl)phenyl)phosphinate

: [4-(2,3-bis-tert-butoxycarbonylamino-propyl)-phenyl]-phenyl-phosphinic acid tert-butyl ester

: 223111-68-0
(S,S)-tert-butyl bis(4-<2,3-di(tert-butoxycarbonylamino)propyl>phenyl)phosphinate

Guidance literature:: With tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; triethylamine; In acetonitrile; at 90 ℃; for 14h;
DOI:10.1021/jo9804590

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 223111-68-0
(S,S)-tert-butyl bis(4-<2,3-di(tert-butoxycarbonylamino)propyl>phenyl)phosphinate

Guidance literature:: Multi-step reaction with 3 steps

1: 21.7 g / NaHCO₃ / methanol / 8 h / Ambient temperature

2: 75 percent / (Ph₃P)2PdCl₂, Et₃N / toluene; acetonitrile / 1.67 h / 90 °C

3: Et₃N, Pd₂(dba)3 / acetonitrile / 14 h / 90 °C

With bis-triphenylphosphine-palladium(II) chloride; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; sodium hydrogencarbonate; triethylamine; In methanol; toluene; acetonitrile;
DOI:10.1021/jo9804590