(E)-(S)-2-Benzyl-7-methyl-oct-4-enoic acid ((1R,2R)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide

Base Information

Chemical Name:(E)-(S)-2-Benzyl-7-methyl-oct-4-enoic acid ((1R,2R)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide
CAS No.:196706-11-3
Molecular Formula:C₂₆H₃₅NO₂
Molecular Weight:393.569
Hs Code.:

Synonyms:(E)-(S)-2-Benzyl-7-methyl-oct-4-enoic acid ((1R,2R)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-(S)-2-Benzyl-7-methyl-oct-4-enoic acid ((1R,2R)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide

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Technology Process of (E)-(S)-2-Benzyl-7-methyl-oct-4-enoic acid ((1R,2R)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide

There total 5 articles about (E)-(S)-2-Benzyl-7-methyl-oct-4-enoic acid ((1R,2R)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 100-39-0
benzyl bromide

: 196706-10-2
(E)-7-Methyl-oct-4-enoic acid ((1R,2R)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide

: 196706-11-3
(E)-(S)-2-Benzyl-7-methyl-oct-4-enoic acid ((1R,2R)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide

Guidance literature:: With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at 0 ℃; for 0.5h;
DOI:10.1021/jo9707951

Reference yield:

: 4798-46-3
5-methylhex-1-en-3-ol

: 196706-11-3
(E)-(S)-2-Benzyl-7-methyl-oct-4-enoic acid ((1R,2R)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) Ti(OEt)4, 2.) KOH / 1.) 190 deg C, 2.) EtOH, reflux

2: 1.) SOCl₂, N,N-dimethylformamide, 2.) Et₃N / 1.) benzene, 23 deg C, 2 h, 2.) THF, 0 deg C, 30 min

3: 76 percent / BuLi, diisopropylamine / tetrahydrofuran; hexane / 0.5 h / 0 °C

With titanium(IV) tetraethanolate; potassium hydroxide; n-butyllithium; thionyl chloride; triethylamine; diisopropylamine; N,N-dimethyl-formamide; In tetrahydrofuran; hexane;
DOI:10.1021/jo9707951

Reference yield:

: 179617-62-0
7-methyl-oct-4-enoic acid

: 196706-11-3
(E)-(S)-2-Benzyl-7-methyl-oct-4-enoic acid ((1R,2R)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) SOCl₂, N,N-dimethylformamide, 2.) Et₃N / 1.) benzene, 23 deg C, 2 h, 2.) THF, 0 deg C, 30 min

2: 76 percent / BuLi, diisopropylamine / tetrahydrofuran; hexane / 0.5 h / 0 °C

With n-butyllithium; thionyl chloride; triethylamine; diisopropylamine; N,N-dimethyl-formamide; In tetrahydrofuran; hexane;
DOI:10.1021/jo9707951