2-(3-ethyl-4-(methyl(1-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)phenoxy)acetonitrile

Base Information

Chemical Name:2-(3-ethyl-4-(methyl(1-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)phenoxy)acetonitrile
CAS No.:1449665-25-1
Molecular Formula:C₁₈H₁₉N₅O
Molecular Weight:321.382
Hs Code.:

Synonyms:2-(3-ethyl-4-(methyl(1-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)phenoxy)acetonitrile

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Chemical Property of 2-(3-ethyl-4-(methyl(1-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)phenoxy)acetonitrile

Chemical Property:

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Technology Process of 2-(3-ethyl-4-(methyl(1-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)phenoxy)acetonitrile

There total 8 articles about 2-(3-ethyl-4-(methyl(1-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)phenoxy)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 607373-83-1
2-chloro-4-methoxy-5-nitro-pyridine

: 1449665-25-1
2-(3-ethyl-4-(methyl(1-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)phenoxy)acetonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrahydrofuran / 2 h / 20 °C

2.1: iron; acetic acid / 1 h / 50 - 80 °C

3.1: 4 h / 100 °C

4.1: caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / 20 h / Inert atmosphere; Reflux

5.1: caesium carbonate / tetrahydrofuran / 0.17 h / Inert atmosphere

5.2: 50 h / 40 °C

6.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / Inert atmosphere

6.2: 16 h

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; iron; sodium hydride; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; acetic acid; In tetrahydrofuran; 1,4-dioxane; mineral oil;

Reference yield:

: 1449669-33-3
[3-ethyl-4-(1-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)phenoxy]acetonitrile

: 74-88-4
methyl iodide

: 1449665-25-1
2-(3-ethyl-4-(methyl(1-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)phenoxy)acetonitrile

Guidance literature:: [3-ethyl-4-(1-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)phenoxy]acetonitrile; With sodium hydride; In tetrahydrofuran; mineral oil; for 0.166667h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; mineral oil; for 16h;

Reference yield:

: 1449506-71-1
(2-chloro-5-nitro-pyridin-4-yl)-methyl-amine

: 1449665-25-1
2-(3-ethyl-4-(methyl(1-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)phenoxy)acetonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: iron; acetic acid / 1 h / 50 - 80 °C

2.1: 4 h / 100 °C

3.1: caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / 20 h / Inert atmosphere; Reflux

4.1: caesium carbonate / tetrahydrofuran / 0.17 h / Inert atmosphere

4.2: 50 h / 40 °C

5.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / Inert atmosphere

5.2: 16 h

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; iron; sodium hydride; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; acetic acid; In tetrahydrofuran; 1,4-dioxane; mineral oil;