2-(3-(1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)phenylamino)-6-isopropylpyrimidin-4(1H)-one

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Chemical Name:2-(3-(1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)phenylamino)-6-isopropylpyrimidin-4(1H)-one
CAS No.:1271802-87-9
Molecular Formula:C₂₄H₂₇N₇O
Molecular Weight:429.525
Hs Code.:

Synonyms:2-(3-(1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)phenylamino)-6-isopropylpyrimidin-4(1H)-one

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Chemical Property of 2-(3-(1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)phenylamino)-6-isopropylpyrimidin-4(1H)-one

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Technology Process of 2-(3-(1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)phenylamino)-6-isopropylpyrimidin-4(1H)-one

There total 5 articles about 2-(3-(1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)phenylamino)-6-isopropylpyrimidin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₅H₂₇N₇O₂S

: 7152-15-0
ethyl 4-methyl-3-oxo-pentanoate

: 1271802-87-9
2-(3-(1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)phenylamino)-6-isopropylpyrimidin-4(1H)-one

Guidance literature:: With potassium carbonate; In methanol; water; at 60 ℃; for 4h;

Reference yield:

: 1271808-46-8
C₃₂H₃₁N₅O₄S

: 1271802-87-9
2-(3-(1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)phenylamino)-6-isopropylpyrimidin-4(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 4 h / 20 °C

2.1: triethylamine / tetrahydrofuran / 12 h / 20 °C

2.2: 1 h / 20 °C

3.1: potassium carbonate / water; methanol / 4 h / 60 °C

With hydrogen; potassium carbonate; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; water;

Reference yield:

: 1271808-42-4
tert-butyl 3-(3-(benzyloxycarbonylamino)phenyl)piperidine-1-carboxylate

: 1271802-87-9
2-(3-(1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)phenylamino)-6-isopropylpyrimidin-4(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / 1,4-dioxane / 20 °C

1.2: 4 h / 90 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 4 h / 20 °C

3.1: triethylamine / tetrahydrofuran / 12 h / 20 °C

3.2: 1 h / 20 °C

4.1: potassium carbonate / water; methanol / 4 h / 60 °C

With hydrogenchloride; hydrogen; potassium carbonate; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; water;