cis/trans-4-(3-fluoro-pyridin-2-yl)-cyclohexanecarboxylic acid ethyl ester

Base Information

Chemical Name:cis/trans-4-(3-fluoro-pyridin-2-yl)-cyclohexanecarboxylic acid ethyl ester
CAS No.:1342802-21-4
Molecular Formula:C₁₄H₁₈FNO₂
Molecular Weight:251.301
Hs Code.:

Synonyms:cis/trans-4-(3-fluoro-pyridin-2-yl)-cyclohexanecarboxylic acid ethyl ester

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Chemical Property of cis/trans-4-(3-fluoro-pyridin-2-yl)-cyclohexanecarboxylic acid ethyl ester

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Technology Process of cis/trans-4-(3-fluoro-pyridin-2-yl)-cyclohexanecarboxylic acid ethyl ester

There total 6 articles about cis/trans-4-(3-fluoro-pyridin-2-yl)-cyclohexanecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1339126-40-7
(RS)-4-(3-fluoro-pyridin-2-yl)-cyclohex-3-enecarboxylic acid ethyl ester

: 1342802-21-4
cis/trans-4-(3-fluoro-pyridin-2-yl)-cyclohexanecarboxylic acid ethyl ester

Guidance literature:: With palladium 10% on activated carbon; hydrogen; triethylamine; at 20 ℃; under 750.075 Torr; Inert atmosphere;

Reference yield: 97.0%

: 1342802-21-4
cis/trans-4-(3-fluoro-pyridin-2-yl)-cyclohexanecarboxylic acid ethyl ester

Guidance literature:

Reference yield:

: 17159-79-4
ethyl 4-oxocyclohexane-1-carboxylate

: 1342802-21-4
cis/trans-4-(3-fluoro-pyridin-2-yl)-cyclohexanecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

1.2: 12.5 h / -78 - 20 °C

2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; 1,1'-bis-(diphenylphosphino)ferrocene / 1,4-dioxane / 18 h / 90 °C / Inert atmosphere

3.1: potassium hydrogenfluoride / water; acetone / 4 h / 20 °C

4.1: potassium carbonate; (1,3-diisopropylimidazol-2-ylidene)(3-chloropyridyl)palladium(II) dichloride / Reflux

5.1: palladium 10% on activated carbon; hydrogen / 20 °C / 750.08 Torr

With 1,1'-bis-(diphenylphosphino)ferrocene; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium hydrogenfluoride; (1,3-diisopropylimidazol-2-ylidene)(3-chloropyridyl)palladium(II) dichloride; palladium 10% on activated carbon; hydrogen; potassium acetate; potassium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; water; acetone; 4.1: |Suzuki Coupling;