trans-4-(3-fluoro-pyridin-2-yl)-cyclohexanecarboxylic acid hydrazide

Base Information

• Chemical Name: trans-4-(3-fluoro-pyridin-2-yl)-cyclohexanecarboxylic acid hydrazide
• CAS No.: 1342802-70-3
• Molecular Formula: C₁₂H₁₆FN₃O
• Molecular Weight: 237.277
• Mol file: 1342802-70-3.mol

Synonyms:trans-4-(3-fluoro-pyridin-2-yl)-cyclohexanecarboxylic acid hydrazide

Chemical Property of trans-4-(3-fluoro-pyridin-2-yl)-cyclohexanecarboxylic acid hydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trans-4-(3-fluoro-pyridin-2-yl)-cyclohexanecarboxylic acid hydrazide

There total 9 articles about trans-4-(3-fluoro-pyridin-2-yl)-cyclohexanecarboxylic acid hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

trans-4-(3-fluoro-pyridin-2-yl)-cyclohexanecarboxylic acid ethyl ester (1342802-22-5) → trans-4-(3-fluoro-pyridin-2-yl)-cyclohexanecarboxylic acid hydrazide (1342802-70-3)

Guidance literature:

With hydrazine hydrate; In butan-1-ol; Reflux;

Reference yield: 100.0%

→ trans-4-(3-fluoro-pyridin-2-yl)-cyclohexanecarboxylic acid hydrazide (1342802-70-3)

Guidance literature:

Reference yield:

(RS)-4-(3-fluoro-pyridin-2-yl)-cyclohex-3-enecarboxylic acid ethyl ester (1339126-40-7) → trans-4-(3-fluoro-pyridin-2-yl)-cyclohexanecarboxylic acid hydrazide (1342802-70-3)

Guidance literature:

Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / 20 °C / 750.08 Torr

2: sodium ethanolate / ethanol / Reflux

3: hydrazine hydrate / butan-1-ol / Reflux

With palladium 10% on activated carbon; hydrogen; sodium ethanolate; hydrazine hydrate; In ethanol; butan-1-ol;

upstream raw materials:

(RS)-4-(3-fluoro-pyridin-2-yl)-cyclohex-3-enecarboxylic acid ethyl ester

trans-4-(3-fluoro-pyridin-2-yl)-cyclohexanecarboxylic acid ethyl ester

cis/trans-4-(3-fluoro-pyridin-2-yl)-cyclohexanecarboxylic acid ethyl ester

ethyl 4-oxocyclohexane-1-carboxylate