4-Ethyl-6-((3R,4R)-7-methoxy-2,2-dimethyl-3-phenyl-chroman-4-yl)-3,4-dihydro-2H-benzo[1,4]oxazine

Base Information

Chemical Name:4-Ethyl-6-((3R,4R)-7-methoxy-2,2-dimethyl-3-phenyl-chroman-4-yl)-3,4-dihydro-2H-benzo[1,4]oxazine
CAS No.:78838-46-7
Molecular Formula:C₂₈H₃₁NO₃
Molecular Weight:429.559
Hs Code.:

Synonyms:4-Ethyl-6-((3R,4R)-7-methoxy-2,2-dimethyl-3-phenyl-chroman-4-yl)-3,4-dihydro-2H-benzo[1,4]oxazine

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Chemical Property of 4-Ethyl-6-((3R,4R)-7-methoxy-2,2-dimethyl-3-phenyl-chroman-4-yl)-3,4-dihydro-2H-benzo[1,4]oxazine

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Technology Process of 4-Ethyl-6-((3R,4R)-7-methoxy-2,2-dimethyl-3-phenyl-chroman-4-yl)-3,4-dihydro-2H-benzo[1,4]oxazine

There total 11 articles about 4-Ethyl-6-((3R,4R)-7-methoxy-2,2-dimethyl-3-phenyl-chroman-4-yl)-3,4-dihydro-2H-benzo[1,4]oxazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 78838-41-2
6-<4'-(3',4'-trans-7'-Methoxy-2',2'-dimethyl-3'-phenyl)chromanyl>dihydrobenz-1,4-oxazine

: 78838-46-7
4-Ethyl-6-((3R,4R)-7-methoxy-2,2-dimethyl-3-phenyl-chroman-4-yl)-3,4-dihydro-2H-benzo[1,4]oxazine

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; for 24h; Ambient temperature;

Reference yield:

: 51423-18-8
cis-2,2-Dimethyl-3-phenyl-4-(p-hydroxyphenyl)-7-methoxychroman

: 78838-46-7
4-Ethyl-6-((3R,4R)-7-methoxy-2,2-dimethyl-3-phenyl-chroman-4-yl)-3,4-dihydro-2H-benzo[1,4]oxazine

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / conc. HNO₃ / acetic acid / 0.5 h / 8 - 10 °C

2: 65 percent / H₂ / 10percent Pd/C / methanol / 1 h / 2585.7 Torr

3: K₂CO₃ / acetone

4: n-butyl-lithium / dimethylsulfoxide / 24 h / Ambient temperature

5: 80 percent / K₂CO₃ / dimethylformamide / 24 h / Ambient temperature

With n-butyllithium; hydrogen; nitric acid; potassium carbonate; palladium on activated charcoal; In methanol; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;

Reference yield:

: 78838-23-0,78838-24-1
3,4-cis-7-Methoxy-2,2-dimethyl-3-phenyl-4-(4'-hydroxy-3'-nitrophenyl)chroman

: 78838-46-7
4-Ethyl-6-((3R,4R)-7-methoxy-2,2-dimethyl-3-phenyl-chroman-4-yl)-3,4-dihydro-2H-benzo[1,4]oxazine

Guidance literature:: Multi-step reaction with 4 steps

1: 65 percent / H₂ / 10percent Pd/C / methanol / 1 h / 2585.7 Torr

2: K₂CO₃ / acetone

3: n-butyl-lithium / dimethylsulfoxide / 24 h / Ambient temperature

4: 80 percent / K₂CO₃ / dimethylformamide / 24 h / Ambient temperature

With n-butyllithium; hydrogen; potassium carbonate; palladium on activated charcoal; In methanol; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;