1-(4-(2-isopropyl-1-oxoisoindolin-5-yl)benzyl)-3-methylimidazolidine-2,4-dione

Base Information

Chemical Name:1-(4-(2-isopropyl-1-oxoisoindolin-5-yl)benzyl)-3-methylimidazolidine-2,4-dione
CAS No.:1295301-37-9
Molecular Formula:C₂₂H₂₃N₃O₃
Molecular Weight:377.443
Hs Code.:

Synonyms:1-(4-(2-isopropyl-1-oxoisoindolin-5-yl)benzyl)-3-methylimidazolidine-2,4-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(4-(2-isopropyl-1-oxoisoindolin-5-yl)benzyl)-3-methylimidazolidine-2,4-dione

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Technology Process of 1-(4-(2-isopropyl-1-oxoisoindolin-5-yl)benzyl)-3-methylimidazolidine-2,4-dione

There total 5 articles about 1-(4-(2-isopropyl-1-oxoisoindolin-5-yl)benzyl)-3-methylimidazolidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.2%

: 864866-47-7
5-bromo-2-(propan-2-yl)-2,3-dihydro-1H-isoindol-1-one

: 1295301-38-0
3-methyl-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)imidazolidine-2,4-dione

: 1295301-37-9
1-(4-(2-isopropyl-1-oxoisoindolin-5-yl)benzyl)-3-methylimidazolidine-2,4-dione

Guidance literature:: With potassium phosphate; tricyclohexylphosphine; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In 1,4-dioxane; water; at 130 ℃; for 0.25h; Microwave irradiation;

Reference yield:

: 1122-91-4
4-bromo-benzaldehyde

: 1295301-37-9
1-(4-(2-isopropyl-1-oxoisoindolin-5-yl)benzyl)-3-methylimidazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hydroxide / methanol / 0.25 h / 0 °C

1.2: 1 h

2.1: dmap / acetonitrile / 42 h / 0 - 80 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 50 - 75 °C / Inert atmosphere

4.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 80 °C

5.1: tricyclohexylphosphine; potassium phosphate / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / 1,4-dioxane; water / 0.25 h / 130 °C / Microwave irradiation

With dmap; potassium phosphate; potassium acetate; potassium carbonate; potassium hydroxide; tricyclohexylphosphine; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 201987-81-7
1-(4-bromobenzyl)imidazolidine-2,4-dione

: 1295301-37-9
1-(4-(2-isopropyl-1-oxoisoindolin-5-yl)benzyl)-3-methylimidazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 50 - 75 °C / Inert atmosphere

2: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 80 °C

3: tricyclohexylphosphine; potassium phosphate / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / 1,4-dioxane; water / 0.25 h / 130 °C / Microwave irradiation

With potassium phosphate; potassium acetate; potassium carbonate; tricyclohexylphosphine; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; water; N,N-dimethyl-formamide;