2-(3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropyl acetate

Base Information

Chemical Name:2-(3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropyl acetate
CAS No.:1263940-57-3
Molecular Formula:C₂₄H₂₂ClN₃O₂
Molecular Weight:419.911
Hs Code.:

Synonyms:2-(3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropyl acetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropyl acetate

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Technology Process of 2-(3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropyl acetate

There total 10 articles about 2-(3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1264296-02-7
2-(3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropan-1-ol

: 75-36-5
acetyl chloride

: 1263940-57-3
2-(3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropyl acetate

Guidance literature:: With triethylamine; In dichloromethane; for 1h;

Reference yield:

: 107449-78-5
ethyl α-methyl-α-benzylacetoacetate

: 1263940-57-3
2-(3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropyl acetate

Guidance literature:: Multi-step reaction with 10 steps

1.1: toluene-4-sulfonic acid; orthoformic acid triethyl ester / 55 °C

2.1: lithium hydroxide / ethylene glycol / 0.5 h / 200 °C

3.1: hydrogenchloride / water

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 2.17 h / 0 °C / Reflux

4.2: 0 °C

5.1: hydrogenchloride; water / acetone / 1 h

6.1: dmap; triethylamine / dichloromethane / 2 h

7.1: 16 h / 125 °C

8.1: hydrogenchloride / 1,4-dioxane; ethanol / 0.25 h / 150 °C / Irradiation with microwave

9.1: sodium methylate / methanol / 1.5 h

10.1: triethylamine / dichloromethane / 1 h

With hydrogenchloride; dmap; lithium aluminium tetrahydride; water; sodium methylate; toluene-4-sulfonic acid; triethylamine; orthoformic acid triethyl ester; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; ethylene glycol; acetone;

Reference yield:

: 1264295-94-4
ethyl2-methyl-2-(2-methyl-1,3-dioxolan-2-yl)-3-phenylpropanoate

: 1263940-57-3
2-(3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropyl acetate

Guidance literature:: Multi-step reaction with 9 steps

1.1: lithium hydroxide / ethylene glycol / 0.5 h / 200 °C

2.1: hydrogenchloride / water

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 2.17 h / 0 °C / Reflux

3.2: 0 °C

4.1: hydrogenchloride; water / acetone / 1 h

5.1: dmap; triethylamine / dichloromethane / 2 h

6.1: 16 h / 125 °C

7.1: hydrogenchloride / 1,4-dioxane; ethanol / 0.25 h / 150 °C / Irradiation with microwave

8.1: sodium methylate / methanol / 1.5 h

9.1: triethylamine / dichloromethane / 1 h

With hydrogenchloride; dmap; lithium aluminium tetrahydride; water; sodium methylate; triethylamine; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; ethylene glycol; acetone;