(2R,3R)-2-(2,4-difluorophenyl)-2-hydroxybutane-1,3-diyl diacetate

Base Information

• Chemical Name: (2R,3R)-2-(2,4-difluorophenyl)-2-hydroxybutane-1,3-diyl diacetate
• CAS No.: 1202852-88-7
• Molecular Formula: C₁₄H₁₆F₂O₅
• Molecular Weight: 302.275
• Mol file: 1202852-88-7.mol

Synonyms:(2R,3R)-2-(2,4-difluorophenyl)-2-hydroxybutane-1,3-diyl diacetate

Chemical Property of (2R,3R)-2-(2,4-difluorophenyl)-2-hydroxybutane-1,3-diyl diacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,3R)-2-(2,4-difluorophenyl)-2-hydroxybutane-1,3-diyl diacetate

There total 2 articles about (2R,3R)-2-(2,4-difluorophenyl)-2-hydroxybutane-1,3-diyl diacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

vinyl acetate (108-05-4,9003-20-7) + (2R*,3R*)-2-(2,4-Difluorophenyl)-1,2,3-butanetriol (126918-20-5,132563-67-8,138457-41-7) → (2R,3R)-2-(2,4-difluorophenyl)-2-hydroxybutane-1,3-diyl diacetate (1202852-88-7)

Guidance literature:

With Lipase PS; In tert-butyl methyl ether; at 20 ℃; for 96h; optical yield given as %ee; enantiospecific reaction; Enzymatic reaction;

DOI:10.1016/j.tetasy.2009.09.024

Reference yield: 17.0%

vinyl acetate (108-05-4,9003-20-7) + 2-(2,4-difluorophenyl)butane-1,2,3-triol (1227936-55-1) → (2S,3R)-2-(2,4-difluorophenyl)-2-hydroxybutane-1,3-diyl diacetate + (2R,3R)-2-(2,4-difluorophenyl)-2-hydroxybutane-1,3-diyl diacetate (1202852-88-7)

Guidance literature:

With Lipase PS; In tert-butyl methyl ether; at 20 ℃; for 96h; enantiospecific reaction; Enzymatic reaction;

DOI:10.1016/j.tetasy.2009.09.024

Reference yield: 89.0%

(2R,3R)-2-(2,4-difluorophenyl)-2-hydroxybutane-1,3-diyl diacetate (1202852-88-7) → (2R,3R)-2-(2,4-difluorophenyl)butane-1,2,3-triol (126918-20-5)

Guidance literature:

With potassium hydroxide; In methanol;

DOI:10.1016/j.tetasy.2009.09.024

upstream raw materials:

vinyl acetate

2-(2,4-difluorophenyl)butane-1,2,3-triol

(2R^*,3R^*)-2-(2,4-Difluorophenyl)-1,2,3-butanetriol

Downstream raw materials:

(2R,3R)-2-(2,4-difluorophenyl)butane-1,2,3-triol