126918-20-5

Basic information

• Product Name: (2R,3R)-2-(2,4-difluorophenyl)butane-1,2,3-triol
• Synonyms: (2R,3R)-2-(2,4-difluorophenyl)butane-1,2,3-triol
• CAS NO: 126918-20-5
• Molecular Weight: 218.2
• Mol File: 126918-20-5.mol

Chemical Properties

• CAS DataBase Reference: (2R,3R)-2-(2,4-difluorophenyl)butane-1,2,3-triol(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3R)-2-(2,4-difluorophenyl)butane-1,2,3-triol(126918-20-5)
• EPA Substance Registry System: (2R,3R)-2-(2,4-difluorophenyl)butane-1,2,3-triol(126918-20-5)

Safety Data

• Hazardous Substances Data: 126918-20-5(Hazardous Substances Data)

Upstream product

• 126918-19-2 (2S,3S)-2-(2,4-Difluoro-phenyl)-3-(tetrahydro-pyran-2-yloxy)-butane-1,2-diol 
• 1202852-83-2 1-(4-(2,4-difluorophenyl)-2,2-dimethyl-1,3-dioxolan-4-yl)ethanol 
• 1202852-88-7 (2R,3R)-2-(2,4-difluorophenyl)-2-hydroxybutane-1,3-diyl diacetate 
• 1610616-81-3 4-(2,4-difluorophenyl)-4-vinyl-1,3-dioxolan-2-one 
• 104-15-4 toluene-4-sulfonic acid 
• 126918-19-2 (2R,3R)-2-(2,4-Difluorophenyl)-3-(2-tetrahydropyranyloxy)-1,2-butanediol 
• 126918-18-1 (2S,3R)-2-(2,4-difluorophenyl)-1-(dimethylisopropoxysilyl)-3-(2-tetrahydropyranyloxy)-2-butanol 
• 126918-15-8 (S)-2-(p-toluenesulfonyloxy)-2',4'-difluoropropiophenone 
• 136926-11-9 Methanesulfonic acid (1S,2R)-2-(2,4-difluoro-phenyl)-2-hydroxy-1-methyl-but-3-enyl ester 
• 137035-03-1 [(2S,3R)-2-(2,4-Difluoro-phenyl)-3-methyl-oxiranyl]-methanol 
• 137035-05-3 (2R,3R)-2-(2,4-Difluoro-phenyl)-3-methyl-oxirane-2-carbaldehyde 
• 137035-04-2 (2R,3R)-2-(2,4-Difluoro-phenyl)-3-methyl-2-vinyl-oxirane 
• 141233-18-3 (2R,3R)-1-Benzyloxy-2-(2,4-difluoro-phenyl)-butane-2,3-diol 
• 126918-18-1 (2S^*,3R^*)-2-(2,4-Difluorophenyl)-1-(dimethylisopropoxysilyl)-3-(tetrahydropyran-2-yloxy)-2-butanol 

Downstream Products

• 1202852-88-7 (2R,3R)-2-(2,4-difluorophenyl)-2-hydroxybutane-1,3-diyl diacetate 
• 126917-48-4 (2R,3R)-3-Azido-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol 
• 124627-86-7 1-(((2R,3S)-2-(2,4-difluorophenyl)-3-methyloxiran-2-yl)-methyl)-1H-1,2,4-triazole 
• 126918-21-6 (2R,3R)-2-(2,4-difluorophenyl)-2-hydroxybutane-1,3-diyl dimethanesulfonate 
• 126916-89-0 [(4S,5R)-5-(2,4-Difluoro-phenyl)-4-methyl-5-[1,2,4]triazol-1-ylmethyl-oxazolidin-3-yl]-(4-trifluoromethyl-phenyl)-methanone 
• 126945-34-4 Methanesulfonic acid (1R,2S)-2-(2,4-difluoro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl ester 
• 126916-45-8 1-[(4R,5S)-5-(2,4-Difluoro-phenyl)-4-methyl-oxazolidin-5-ylmethyl]-1H-[1,2,4]triazole 
• 132507-89-2 (2R,3S)-2-(2,4-Difluoro-phenyl)-1-[1,2,4]triazol-1-yl-butane-2,3-diol 
• 126916-57-2 (2R,3S)-3-Amino-2-(2,4-difluoro-phenyl)-1-[1,2,4]triazol-1-yl-butan-2-ol 
• 124627-86-7 (2R^*,3S^*)-2-(2,4-Difluorophenyl)-3-methyl-2-<(1H-1,2,4-triazol-1-yl)methyl>oxirane 
• 124627-86-7 1-[(2S,3S)-2-(2,4-Difluoro-phenyl)-3-methyl-oxiranylmethyl]-1H-[1,2,4]triazole 
• 132507-77-8 Trifluoro-acetic acid (1R,2S)-2-(2,4-difluoro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl ester 
• 126918-36-3 Methanesulfonic acid (S)-1-[(R)-2-(2,4-difluoro-phenyl)-oxiranyl]-ethyl ester 
• 126918-21-6 (2R^*,3R^*)-2-(2,4-Difluorophenyl)-1,3-bis(methanesulfonyloxy)-2-butanol 

Relevant articles and documents

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An efficient method for the enantioselective construction of tertiary C-O bond via asymmetric allylic substitution of racemic vinylethylene carbonates with water and alcohols has been developed. Under the cooperative catalysis system of an in situ generated chiral palladium complex and boron reagent in mild conditions, the process allowed rapid access to valuable tertiary alcohols and ethers in high yields with complete regioselectivities and high enantioselectivities. This protocol represented the first example of direct enantioselective formation of a tertiary C-O bond with water as an oxygen donor. The synthetic utilities of the process have been demonstrated by the elaboration of the products into key intermediates of biologically relevant agents, and chiral tertiary cyclic ethers could also be provided through the sequential reactions of the allylic etherification and ring-closing metathesis.

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Compounds of formula (I): in which: Ar is optionally substituted phenyl; R1 is hydrogen or alkyl; X is optionally unsaturated alkylene, cycloalkylene or both; mis 0 or 1; -Yn-R2 is azido, phthalimido, 1-oxo-2,3-dihydro-2-isoindolyl, protected hydroxy or -OSO2R4 (in which R4 is alkyl group, haloalkyl or optionally substituted phenyl); or Y represents a group of formula -N(R5)CO-, -N(R5)CO-CH=CH-, -O-CO-, -O-CO-CH=CH-, -S-CO- or -S-CO-CH=CH- (in which R5 is hydrogen or alkyl); nis 0 or 1; R2 is alkyl, haloalkyl or optionally substituted phenyl, naphthyl or heterocyclic; and R3 is hydrogen; or R3 and -Xm-Yn-R2 together are a group of formula (II): in which R2 is as defined above, pis 0 or 1, and qis 0 or 1;, and acid addition salts thereof are fungicides, which find considerable value in the eradication of fungi in both agriculture and medicine.