2-{2-[(4-methoxy-2,6-dimethylbenzenesulphonyl)methylamino]ethoxy}-N-methyl-N-[(1S,3R)-3-(4-methylpiperazin-1-yl)cyclohexyl]acetamide

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Chemical Name:2-{2-[(4-methoxy-2,6-dimethylbenzenesulphonyl)methylamino]ethoxy}-N-methyl-N-[(1S,3R)-3-(4-methylpiperazin-1-yl)cyclohexyl]acetamide
CAS No.:1119282-90-4
Molecular Formula:C₂₆H₄₄N₄O₅S
Molecular Weight:524.725
Hs Code.:

Synonyms:2-{2-[(4-methoxy-2,6-dimethylbenzenesulphonyl)methylamino]ethoxy}-N-methyl-N-[(1S,3R)-3-(4-methylpiperazin-1-yl)cyclohexyl]acetamide

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Chemical Property of 2-{2-[(4-methoxy-2,6-dimethylbenzenesulphonyl)methylamino]ethoxy}-N-methyl-N-[(1S,3R)-3-(4-methylpiperazin-1-yl)cyclohexyl]acetamide

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Technology Process of 2-{2-[(4-methoxy-2,6-dimethylbenzenesulphonyl)methylamino]ethoxy}-N-methyl-N-[(1S,3R)-3-(4-methylpiperazin-1-yl)cyclohexyl]acetamide

There total 11 articles about 2-{2-[(4-methoxy-2,6-dimethylbenzenesulphonyl)methylamino]ethoxy}-N-methyl-N-[(1S,3R)-3-(4-methylpiperazin-1-yl)cyclohexyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1240308-11-5
{2-[(4-methoxy-2,6-dimethylbenzenesulphonyl)methylamino]ethoxy}acetic acid sodium salt

: methyl [(1S,3R)-3-(4-methylpiperazin-1-yl)cyclohexyl]amine trihydrochloride

: 1119282-90-4
2-{2-[(4-methoxy-2,6-dimethylbenzenesulphonyl)methylamino]ethoxy}-N-methyl-N-[(1S,3R)-3-(4-methylpiperazin-1-yl)cyclohexyl]acetamide

Guidance literature:: With potassium tert-butylate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In tetrahydrofuran; toluene; at 30 ℃; for 0.5h; Large scale;

Reference yield:

: 885280-38-6,1803033-61-5,1383797-87-2
(3-oxo-cyclohexyl)-carbamic acid tert-butyl ester

: 1119282-90-4
2-{2-[(4-methoxy-2,6-dimethylbenzenesulphonyl)methylamino]ethoxy}-N-methyl-N-[(1S,3R)-3-(4-methylpiperazin-1-yl)cyclohexyl]acetamide

: 1119282-87-9
2-{2-[(4-methoxy-2,6-dimethylbenzenesulphonyl)methylamino]ethoxy}-N-methyl-N-[(1R,3S)-3-(4-methylpiperazin-1-yl)cyclohexyl]acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid / methanol / 0.5 h / 20 °C

1.2: 2 h / 20 °C

2.1: lithium aluminium tetrahydride / toluene; tetrahydrofuran / 20 - 75 °C

3.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 2 h / 20 °C

4.1: Daicel OJ-H / Resolution of racemate

With lithium aluminium tetrahydride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; acetic acid; triethylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene;