5-(3-bromo-phenyl)-3-oxo-5-(toluene-4-sulfonylamino)-pentanoic acid ethyl ester

Base Information

Chemical Name:5-(3-bromo-phenyl)-3-oxo-5-(toluene-4-sulfonylamino)-pentanoic acid ethyl ester
CAS No.:942301-17-9
Molecular Formula:C₂₀H₂₂BrNO₅S
Molecular Weight:468.368
Hs Code.:

Synonyms:5-(3-bromo-phenyl)-3-oxo-5-(toluene-4-sulfonylamino)-pentanoic acid ethyl ester

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Chemical Property of 5-(3-bromo-phenyl)-3-oxo-5-(toluene-4-sulfonylamino)-pentanoic acid ethyl ester

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Technology Process of 5-(3-bromo-phenyl)-3-oxo-5-(toluene-4-sulfonylamino)-pentanoic acid ethyl ester

There total 1 articles about 5-(3-bromo-phenyl)-3-oxo-5-(toluene-4-sulfonylamino)-pentanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 141-97-9
ethyl acetoacetate

: 863401-20-1
(E)-N-(3-bromobenzylidene)-4-methylbenzenesulfonamide

: 942301-17-9
5-(3-bromo-phenyl)-3-oxo-5-(toluene-4-sulfonylamino)-pentanoic acid ethyl ester

Guidance literature:: ethyl acetoacetate; With n-butyllithium; diisopropylamine; In tetrahydrofuran; at -50 ℃; for 1h;

(E)-N-(3-bromobenzylidene)-4-methylbenzenesulfonamide; In tetrahydrofuran; at -50 ℃;
DOI:10.1016/j.tet.2007.03.081

Reference yield: 80.0%

: 942301-17-9
5-(3-bromo-phenyl)-3-oxo-5-(toluene-4-sulfonylamino)-pentanoic acid ethyl ester

: 107-21-1
ethylene glycol

: 942301-30-6
{2-[2-(3-bromo-phenyl)-2-(toluene-4-sulfonylamino)-ethyl]-[1,3]dioxolan-2-yl}-acetic acid ethyl ester

Guidance literature:: With toluene-4-sulfonic acid; In benzene; Heating;
DOI:10.1016/j.tet.2007.03.081

Reference yield:

: 942301-17-9
5-(3-bromo-phenyl)-3-oxo-5-(toluene-4-sulfonylamino)-pentanoic acid ethyl ester

: 7-(3-bromo-phenyl)-8-(toluene-4-sulfonyl)-1,4-dioxa-8-aza-spiro[4.5]decane

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / p-toluenesulfonic acid / benzene / Heating

2: LiAlH₄ / tetrahydrofuran / 1 h / 20 °C

3: 418 mg / KOH; TsCl / tetrahydrofuran / 0.5 h / Heating

With potassium hydroxide; lithium aluminium tetrahydride; toluene-4-sulfonic acid; p-toluenesulfonyl chloride; In tetrahydrofuran; benzene;
DOI:10.1016/j.tet.2007.03.081