GLYCINE-2,2-D2-N-T-BOC

Base Information

• Chemical Name: GLYCINE-2,2-D2-N-T-BOC
• CAS No.: 42492-65-9
• Molecular Formula: C7H11 D2 N O4
• Molecular Weight: 177.169
• Mol file: 42492-65-9.mol

Synonyms:GLYCINE-2,2-D2-N-T-BOC;BOC-GLY-OH-2,2-D2;N-(tert-Butoxycarbonyl)glycine-2,2-d2, Glycine-2,2-d2, N-t-Boc derivative

Chemical Property of GLYCINE-2,2-D2-N-T-BOC

Chemical Property:

• Melting Point: 86-89 °C(lit.)
• PSA: 75.63000
• LogP: 0.98660

Purity/Quality:

N-[(1,1-Dimethylethoxy)carbonyl]glycine-2,2-d2 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N-[(1,1-Dimethylethoxy)carbonyl]glycine-2,2-d2 is a reagent in the identification of a ERα17p, a peptide reproducing the hinge region of the estrogen receptor α, which exerts pharmacological efffects in breast cancer cells.

Technology Process of GLYCINE-2,2-D2-N-T-BOC

There total 2 articles about GLYCINE-2,2-D2-N-T-BOC which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

<2-2H2>glycine (4896-75-7) + 2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile (58632-95-4) → N-(tert-butoxycarbonyl)glycine-2,2-d2 (42492-65-9)

Guidance literature:

With triethylamine; In 1,4-dioxane; water; for 2h; Ambient temperature;

DOI:10.1021/ja00307a034

Reference yield: 80.0%

<2-2H2>glycine (4896-75-7) + di-tert-butyl dicarbonate (24424-99-5) → N-(tert-butoxycarbonyl)glycine-2,2-d2 (42492-65-9)

Guidance literature:

With triethylamine; In 1,4-dioxane; water; at 20 ℃; for 2h;

DOI:10.1021/ja0558894

Reference yield: 93.0%

(-)-8-phenylmenthol (65253-04-5) + N-(tert-butoxycarbonyl)glycine-2,2-d2 (42492-65-9) → (1R,2S,5R)-2-(1-methyl-1-phenylethyl)-5-methylcyclohexyl 2-<(tert-butoxycarbonyl)amino>-2,2-dideuterioacetate (151132-90-0)

Guidance literature:

DOI:10.1016/S0040-4020(01)80156-3

upstream raw materials:

<2-2H2>glycine

2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile

di-tert-butyl dicarbonate

Downstream raw materials:

(1R,2S,5R)-2-(1-methyl-1-phenylethyl)-5-methylcyclohexyl 2-<(tert-butoxycarbonyl)amino>-2,2-dideuterioacetate

C₁₈H₂₃⁽²⁾H₂N₃O₆

C₂₇H₃₆⁽²⁾H₂N₆O₉

C₂₅H₃₃⁽²⁾H₂N₅O₈

Refernces

• 1、 Matta, Michael S.,Andracki, Mark E.. "Rate-Controlling Step of Oxazolinone Formation. Secondary and Solvent Kinetic Isotope Effects". . p. 6036 - 6039. Retrieved 2007/10/02.