(4S,5R)-(-)-5-ethyl-1-(4-hydroxy-3-methoxyphenethyl)-2-oxo-4-piperidineacetic acid ethyl ester

Base Information

• Chemical Name: (4S,5R)-(-)-5-ethyl-1-(4-hydroxy-3-methoxyphenethyl)-2-oxo-4-piperidineacetic acid ethyl ester
• CAS No.: 82310-52-9
• Molecular Formula: C₂₀H₂₉NO₅
• Molecular Weight: 363.454

Synonyms:(4S,5R)-(-)-5-ethyl-1-(4-hydroxy-3-methoxyphenethyl)-2-oxo-4-piperidineacetic acid ethyl ester

Chemical Property of (4S,5R)-(-)-5-ethyl-1-(4-hydroxy-3-methoxyphenethyl)-2-oxo-4-piperidineacetic acid ethyl ester

Chemical Property:

Purity/Quality:

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Technology Process of (4S,5R)-(-)-5-ethyl-1-(4-hydroxy-3-methoxyphenethyl)-2-oxo-4-piperidineacetic acid ethyl ester

There total 11 articles about (4S,5R)-(-)-5-ethyl-1-(4-hydroxy-3-methoxyphenethyl)-2-oxo-4-piperidineacetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(4S,5R)-1-<2-(4-benzyloxy-3-methoxyphenyl)-2-hydroxyethyl>-5-ethyl-2-oxo-4-piperidineacetic acid ethyl ester (73053-70-0,82260-57-9,82260-58-0,96896-22-9,96896-23-0,115075-69-9,115075-70-2) → (4S,5R)-(-)-5-ethyl-1-(4-hydroxy-3-methoxyphenethyl)-2-oxo-4-piperidineacetic acid ethyl ester (82310-52-9)

Guidance literature:

With perchloric acid; hydrogen; palladium on activated charcoal; In ethanol; at 35 ℃; for 16h; under 760 Torr;

Reference yield: 97.0%

(+/-)-trans-1-<2-(4-benzyloxy-3-methoxyphenyl)-2-hydroxyethyl>-5-ethyl-2-oxo-4-piperidineacetic acid ethyl ester (73053-70-0,82260-57-9,82260-58-0,96896-22-9,96896-23-0,115075-69-9,115075-70-2) → (+/-)-trans-5-ethyl-1-(4-hydroxy-3-methoxyphenethyl)-2-oxo-4-piperidineacetic acid ethyl ester (73053-71-1,82310-52-9,82310-90-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; In perchloric acid; ethanol; for 12h; Ambient temperature;

Reference yield: 8.2%

(3R,4S)-1-<2-(4-benzyloxy-3-methyloxyphenyl)-2-hydroxyethyl>-3-ethyl-4-piperidineacetic acid ethyl ester (82260-55-7,82260-56-8) → {(S)-1-[2-Acetoxy-2-(4-benzyloxy-3-methoxy-phenyl)-ethyl]-3-ethyl-2-oxo-piperidin-4-yl}-acetic acid ethyl ester (98325-30-5,109741-50-6,109741-51-7) + {(4S,5R)-1-[2-Acetoxy-2-(4-benzyloxy-3-methoxy-phenyl)-ethyl]-5-ethyl-2-oxo-piperidin-4-yl}-acetic acid ethyl ester (98325-31-6,98325-32-7) + (4S,5R)-1-<2-(4-benzyloxy-3-methoxyphenyl)-2-hydroxyethyl>-5-ethyl-2-oxo-4-piperidineacetic acid ethyl ester (73053-70-0,82260-57-9,82260-58-0,96896-22-9,96896-23-0,115075-69-9,115075-70-2) + (4S,5R)-(-)-5-ethyl-1-(4-hydroxy-3-methoxyphenethyl)-2-oxo-4-piperidineacetic acid ethyl ester (82310-52-9)

Guidance literature:

With mercury(II) diacetate; edetate disodium dihydrate; acetic acid; In water; for 1.5h; Heating;

upstream raw materials:

(+/-)-trans-1-<2-(4-benzyloxy-3-methoxyphenyl)-2-hydroxyethyl>-5-ethyl-2-oxo-4-piperidineacetic acid ethyl ester

3-methoxy-4-benzyloxy-α-bromoacetophenone

((3S,4S)-6-Ethoxy-3-ethyl-2,3,4,5-tetrahydro-pyridin-4-yl)-acetic acid ethyl ester

(+/-)-trans-1-(4-benzyloxy-3-methoxyphenacyl)-5-ethyl-2-oxo-4-piperidineacetic acid ethyl ester

Downstream raw materials:

(+/-)-trans-1-(4-benzyloxy-3-methoxyphenethyl)-5-ethyl-2-oxo-4-piperidineacetic acid ethyl ester

(4S,5R)-(-)-5-ethyl-1-(4-hydroxy-3-methoxyphenethyl)-2-oxo-4-piperidineacetic acid

(+/-)-10-benzyloxy-3α-ethyl-1,3,4,6,7,11bα-hexahydro-9-methoxy-2H-benzoquinolizine-2β-acetic acid ethyl ester

(+/-)-10-benzyloxy-3α-ethyl-1,3,4,6,7,11bα-hexahydro-9-methoxy-2H-benzoquinolizine-2β-acetic acid

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