(4S,5R)-(-)-5-ethyl-1-(4-hydroxy-3-methoxyphenethyl)-2-oxo-4-piperidineacetic acid

Base Information

Chemical Name:(4S,5R)-(-)-5-ethyl-1-(4-hydroxy-3-methoxyphenethyl)-2-oxo-4-piperidineacetic acid
CAS No.:82260-59-1
Molecular Formula:C₁₈H₂₅NO₅
Molecular Weight:335.4
Hs Code.:

Synonyms:(4S,5R)-(-)-5-ethyl-1-(4-hydroxy-3-methoxyphenethyl)-2-oxo-4-piperidineacetic acid

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Chemical Property of (4S,5R)-(-)-5-ethyl-1-(4-hydroxy-3-methoxyphenethyl)-2-oxo-4-piperidineacetic acid

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Technology Process of (4S,5R)-(-)-5-ethyl-1-(4-hydroxy-3-methoxyphenethyl)-2-oxo-4-piperidineacetic acid

There total 7 articles about (4S,5R)-(-)-5-ethyl-1-(4-hydroxy-3-methoxyphenethyl)-2-oxo-4-piperidineacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 82310-52-9
(4S,5R)-(-)-5-ethyl-1-(4-hydroxy-3-methoxyphenethyl)-2-oxo-4-piperidineacetic acid ethyl ester

: 82260-59-1
(4S,5R)-(-)-5-ethyl-1-(4-hydroxy-3-methoxyphenethyl)-2-oxo-4-piperidineacetic acid

Guidance literature:: With sodium hydroxide; In ethanol; water; at 25 ℃; for 24h;

Reference yield:

: 73053-70-0,82260-57-9,82260-58-0,96896-22-9,96896-23-0,115075-69-9,115075-70-2
(4S,5R)-1-<2-(4-benzyloxy-3-methoxyphenyl)-2-hydroxyethyl>-5-ethyl-2-oxo-4-piperidineacetic acid ethyl ester

: 82260-59-1
(4S,5R)-(-)-5-ethyl-1-(4-hydroxy-3-methoxyphenethyl)-2-oxo-4-piperidineacetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / H₂ / 10percent Pd-C / ethanol; H₂O; HClO₄ / 16 h / 35 °C / 760 Torr

2: 98 percent / 2 N aq. NaOH / ethanol / 24 h / 25 °C

With sodium hydroxide; hydrogen; palladium on activated charcoal; In perchloric acid; ethanol; water;

Reference yield:

: 1835-12-7
3-methoxy-4-benzyloxy-α-bromoacetophenone

: 82260-59-1
(4S,5R)-(-)-5-ethyl-1-(4-hydroxy-3-methoxyphenethyl)-2-oxo-4-piperidineacetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / K₂CO₃ / benzene / 7 h / 50 - 55 °C

2: 97 percent / NaBH₄ / ethanol / 1.) 0 deg C, 2 h, 2.) RT, 6 h

3: 53 percent / Hg(OAc)2-EDTA / acetic acid; H₂O / 1.5 h / Heating

4: 99 percent / H₂ / 10percent Pd-C / ethanol; H₂O; HClO₄ / 16 h / 35 °C / 760 Torr

5: 98 percent / 2 N aq. NaOH / ethanol / 24 h / 25 °C

With sodium hydroxide; sodium tetrahydroborate; Hg(OAc)2*EDTA; hydrogen; potassium carbonate; palladium on activated charcoal; In perchloric acid; ethanol; water; acetic acid; benzene;