N-benzoyl-(3-NO₂)-L-phenylglycine

Base Information

• Chemical Name: N-benzoyl-(3-NO₂)-L-phenylglycine
• CAS No.: 1335096-53-1
• Molecular Formula: C₁₅H₁₂N₂O₅
• Molecular Weight: 300.271
• Mol file: 1335096-53-1.mol

Synonyms:N-benzoyl-(3-NO₂)-L-phenylglycine

Chemical Property of N-benzoyl-(3-NO₂)-L-phenylglycine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-benzoyl-(3-NO₂)-L-phenylglycine

There total 5 articles about N-benzoyl-(3-NO₂)-L-phenylglycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

N-benzoyl-(3-nitro)-L-phenylglycine methyl ester → N-benzoyl-(3-NO2)-L-phenylglycine (1335096-53-1)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; water; at 0 ℃; for 1h;

DOI:10.1021/acs.jmedchem.5b00612

Reference yield: 49.0%

benzoyl chloride (98-88-4) + (3-nitro)-L-phenylglycine (158413-55-9) → N-benzoyl-(3-NO2)-L-phenylglycine (1335096-53-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; Inert atmosphere;

DOI:10.1021/acs.jmedchem.6b01021

Reference yield:

(S)-2-phenylglycine (2935-35-5) → N-benzoyl-(3-NO2)-L-phenylglycine (1335096-53-1)

Guidance literature:

Multi-step reaction with 4 steps

1: nitric acid; sulfuric acid / 0 °C

2: thionyl chloride / 1 h / 0 °C / Reflux

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

4: lithium hydroxide / tetrahydrofuran; water / 1 h / 0 °C

With thionyl chloride; sulfuric acid; nitric acid; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; dichloromethane; water;

DOI:10.1021/acs.jmedchem.5b00612

upstream raw materials:

(3-nitro)-L-phenylglycine

(S)-2-phenylglycine

benzoyl chloride