Technology Process of [(2R,4R,6S)-6-((2RS,6R)-7-benzyloxy-2-hydroxy-4-oxo-6-triethylsilanyloxyheptyl)-2-(4-methoxyphenyl)-[1,3]dioxan-4-yl]acetic acid tert-butyl ester
There total 11 articles about [(2R,4R,6S)-6-((2RS,6R)-7-benzyloxy-2-hydroxy-4-oxo-6-triethylsilanyloxyheptyl)-2-(4-methoxyphenyl)-[1,3]dioxan-4-yl]acetic acid tert-butyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: LDA / tetrahydrofuran; hexane / 1 h
1.2: tetrahydrofuran; hexane / 0.5 h / Heating
2.1: 87.3 g / Et2BOMe; NaBH4 / tetrahydrofuran; methanol
3.1: PPTS / CH2Cl2 / 2.5 h / Heating
4.1: 33.0 g / tetrabutylammonium fluoride trihydrate / tetrahydrofuran / 1 h
5.1: Et3N / CH2Cl2 / 4.25 h / 20 °C
6.1: NaI; NaHCO3; Na2SO3 / butan-2-one / 16 h / Heating
7.1: Li2CuCl4 / tetrahydrofuran
8.1: O3 / CH2Cl2; methanol / 1 h
8.2: 33.6 g / tributylphosphine / CH2Cl2; methanol / 0.17 h
9.1: LDA / tetrahydrofuran; hexane / 1 h
9.2: 50.8 g / tetrahydrofuran; hexane / 0.25 h
With
sodium tetrahydroborate; dilithium tetrachlorocuprate; diethyl methoxy borane; tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate; sodium hydrogencarbonate; ozone; triethylamine; sodium iodide; sodium sulfite; lithium diisopropyl amide;
In
tetrahydrofuran; methanol; hexane; dichloromethane; butanone;
1.2: Claisen condensation;
DOI:10.1021/ja030316h
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: imidazole / dimethylformamide / 0 - 20 °C
2.1: O3; NaHCO3 / methanol; CH2Cl2
2.2: 51.1 g / dimethyl sulfide / methanol; CH2Cl2 / 12 h
3.1: LDA / tetrahydrofuran; hexane / 1 h
3.2: 50.8 g / tetrahydrofuran; hexane / 0.25 h
With
1H-imidazole; sodium hydrogencarbonate; ozone; lithium diisopropyl amide;
In
tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja030316h
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: Et3N / CH2Cl2 / 4.25 h / 20 °C
2.1: NaI; NaHCO3; Na2SO3 / butan-2-one / 16 h / Heating
3.1: Li2CuCl4 / tetrahydrofuran
4.1: O3 / CH2Cl2; methanol / 1 h
4.2: 33.6 g / tributylphosphine / CH2Cl2; methanol / 0.17 h
5.1: LDA / tetrahydrofuran; hexane / 1 h
5.2: 50.8 g / tetrahydrofuran; hexane / 0.25 h
With
dilithium tetrachlorocuprate; sodium hydrogencarbonate; ozone; triethylamine; sodium iodide; sodium sulfite; lithium diisopropyl amide;
In
tetrahydrofuran; methanol; hexane; dichloromethane; butanone;
DOI:10.1021/ja030316h
