Technology Process of tert-butyl (2S,4R,6S)-2-(4-methoxyphenyl)-6-(2-oxoethyl)-[1,3]dioxan-4-ylacetate
There total 8 articles about tert-butyl (2S,4R,6S)-2-(4-methoxyphenyl)-6-(2-oxoethyl)-[1,3]dioxan-4-ylacetate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
tert-butyl (3R,5S)-[6-allyl-2-(4-methoxyphenyl)-[1,3]dioxan-4-yl]acetate;
With
ozone;
In
methanol; dichloromethane;
for 1h;
With
tributylphosphine;
In
methanol; dichloromethane;
for 0.166667h;
DOI:10.1021/ja030316h
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: LDA / tetrahydrofuran; hexane / 1 h
1.2: tetrahydrofuran; hexane / 0.5 h / Heating
2.1: 87.3 g / Et2BOMe; NaBH4 / tetrahydrofuran; methanol
3.1: PPTS / CH2Cl2 / 2.5 h / Heating
4.1: 33.0 g / tetrabutylammonium fluoride trihydrate / tetrahydrofuran / 1 h
5.1: Et3N / CH2Cl2 / 4.25 h / 20 °C
6.1: NaI; NaHCO3; Na2SO3 / butan-2-one / 16 h / Heating
7.1: Li2CuCl4 / tetrahydrofuran
8.1: O3 / CH2Cl2; methanol / 1 h
8.2: 33.6 g / tributylphosphine / CH2Cl2; methanol / 0.17 h
With
sodium tetrahydroborate; dilithium tetrachlorocuprate; diethyl methoxy borane; tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate; sodium hydrogencarbonate; ozone; triethylamine; sodium iodide; sodium sulfite; lithium diisopropyl amide;
In
tetrahydrofuran; methanol; hexane; dichloromethane; butanone;
1.2: Claisen condensation;
DOI:10.1021/ja030316h
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: Et3N / CH2Cl2 / 4.25 h / 20 °C
2.1: NaI; NaHCO3; Na2SO3 / butan-2-one / 16 h / Heating
3.1: Li2CuCl4 / tetrahydrofuran
4.1: O3 / CH2Cl2; methanol / 1 h
4.2: 33.6 g / tributylphosphine / CH2Cl2; methanol / 0.17 h
With
dilithium tetrachlorocuprate; sodium hydrogencarbonate; ozone; triethylamine; sodium iodide; sodium sulfite;
In
tetrahydrofuran; methanol; dichloromethane; butanone;
DOI:10.1021/ja030316h
![tert-butyl (3R,5S)-[6-allyl-2-(4-methoxyphenyl)-[1,3]dioxan-4-yl]acetate](/Databaselist/images/loading.webp)
