benzyl 4-(2-amino-2-oxo-ethyl)-4-[[5-cyclopropyl-6-(cyclopropylmethoxy)pyridine-2-carbonyl]amino]piperidine-1-carboxylate

Base Information

• Chemical Name: benzyl 4-(2-amino-2-oxo-ethyl)-4-[[5-cyclopropyl-6-(cyclopropylmethoxy)pyridine-2-carbonyl]amino]piperidine-1-carboxylate
• CAS No.: 1613298-71-7
• Molecular Formula: C₂₈H₃₄N₄O₅
• Molecular Weight: 506.602
• Mol file: 1613298-71-7.mol

Synonyms:benzyl 4-(2-amino-2-oxo-ethyl)-4-[[5-cyclopropyl-6-(cyclopropylmethoxy)pyridine-2-carbonyl]amino]piperidine-1-carboxylate

Chemical Property of benzyl 4-(2-amino-2-oxo-ethyl)-4-[[5-cyclopropyl-6-(cyclopropylmethoxy)pyridine-2-carbonyl]amino]piperidine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl 4-(2-amino-2-oxo-ethyl)-4-[[5-cyclopropyl-6-(cyclopropylmethoxy)pyridine-2-carbonyl]amino]piperidine-1-carboxylate

There total 5 articles about benzyl 4-(2-amino-2-oxo-ethyl)-4-[[5-cyclopropyl-6-(cyclopropylmethoxy)pyridine-2-carbonyl]amino]piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

5-cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid (1415898-71-3) + benzyl 4-amino-4-(2-amino-2-oxoethyl)piperidine-1-carboxylate hydrochloride (1613298-69-3) → benzyl 4-(2-amino-2-oxo-ethyl)-4-[[5-cyclopropyl-6-(cyclopropylmethoxy)pyridine-2-carbonyl]amino]piperidine-1-carboxylate (1613298-71-7)

Guidance literature:

With 2-bromo-1-ethylpyridin-1-ium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 48h; Cooling with ice;

Reference yield:

methyl 5-bromopicolinate (29682-15-3) → benzyl 4-(2-amino-2-oxo-ethyl)-4-[[5-cyclopropyl-6-(cyclopropylmethoxy)pyridine-2-carbonyl]amino]piperidine-1-carboxylate (1613298-71-7)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 h / 60 °C

2.1: trichlorophosphate / 2 h / 0 - 95 °C

3.1: sodium hydride / mineral oil / 1 h / 0 °C

3.2: 2 h / 90 °C

4.1: palladium diacetate; tricyclohexylphosphine; potassium phosphate / toluene; water / 100 °C

5.1: 2-bromo-1-ethylpyridin-1-ium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 48 h / 20 °C / Cooling with ice

With potassium phosphate; palladium diacetate; 2-bromo-1-ethylpyridin-1-ium tetrafluoroborate; sodium hydride; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; tricyclohexylphosphine; In tetrahydrofuran; dichloromethane; water; toluene; mineral oil;

Reference yield:

5-bromo-2-(methoxycarbonyl)-1A[5]-pyridin-1-olate (959741-32-3) → benzyl 4-(2-amino-2-oxo-ethyl)-4-[[5-cyclopropyl-6-(cyclopropylmethoxy)pyridine-2-carbonyl]amino]piperidine-1-carboxylate (1613298-71-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: trichlorophosphate / 2 h / 0 - 95 °C

2.1: sodium hydride / mineral oil / 1 h / 0 °C

2.2: 2 h / 90 °C

3.1: palladium diacetate; tricyclohexylphosphine; potassium phosphate / toluene; water / 100 °C

4.1: 2-bromo-1-ethylpyridin-1-ium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 48 h / 20 °C / Cooling with ice

With potassium phosphate; palladium diacetate; 2-bromo-1-ethylpyridin-1-ium tetrafluoroborate; sodium hydride; N-ethyl-N,N-diisopropylamine; trichlorophosphate; tricyclohexylphosphine; In tetrahydrofuran; water; toluene; mineral oil;

upstream raw materials:

5-cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid

benzyl 4-amino-4-(2-amino-2-oxoethyl)piperidine-1-carboxylate hydrochloride

5-bromo-6-chloro-pyridine-2-carboxylic acid methyl ester

5-bromo-6-(cyclopropylmethoxy)pyridine-2-carboxylic acid