959741-32-3

Basic information

• Product Name: 5-bromo-2-(methoxycarbonyl)-1^A[5]-pyridin-1-olate
• CAS NO: 959741-32-3
• Molecular Weight: 232.034
• Mol File: 959741-32-3.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 5-bromo-2-(methoxycarbonyl)-1^A[5]-pyridin-1-olate(CAS DataBase Reference)
• NIST Chemistry Reference: 5-bromo-2-(methoxycarbonyl)-1^A[5]-pyridin-1-olate(959741-32-3)
• EPA Substance Registry System: 5-bromo-2-(methoxycarbonyl)-1^A[5]-pyridin-1-olate(959741-32-3)

Safety Data

• Hazardous Substances Data: 959741-32-3(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 959741-37-8 5-bromo-2-carboxypyridin-1-ium-1-olate 
• 30766-11-1 5-bromoisonicotinic acid 
• 29682-15-3 methyl 5-bromopicolinate 

Downstream Products

• 959741-33-4 methyl 5-bromo-6-cyanopyridine-2-carboxylate 
• 959958-25-9 5-bromo-6-chloropyridine-2-carboxylic acid 

Relevant articles and documents

PESTICIDAL AND PARASITICIDAL VINYL ISOXAZOLINE COMPOUNDS

The present invention relates to pesticidal and parasiticidal isoxazoline of formula (I) and salts thereof: Formula (I) wherein variables B1, B2, B3, R1, P1, P2, Y and Q are described herein are as defined in the description. The invention also relates to parasiticidal and pesticidal compositions comprising the isoxazoline compounds of formula (I), processes for their preparation and their uses to prevent or treat parasitic infections or infestations in animals and as pesticides.

Discovery of a high affinity and selective pyridine analog as a potential positron emission tomography imaging agent for cannabinoid type 2 receptor

As part of our efforts to develop CB2 PET imaging agents, we investigated 2,5,6-substituted pyridines as a novel class of potential CB2 PET ligands. A total of 21 novel compounds were designed, synthesized, and evaluated for their potency and binding properties toward human and rodent CB1 and CB2. The most promising ligand 6a was radiolabeled with carbon-11 to yield 16 ([11C]RSR-056). Specific binding of 16 to CB2-positive spleen tissue of rats and mice was demonstrated by in vitro autogadiography and verified in vivo in PET and biodistribution experiments. Furthermore, 16 was evaluated in a lipopolysaccharid (LPS) induced murine model of neuroinflammation. Brain radioactivity was strikingly higher in the LPS-treated mice than the control mice. Compound 16 is a promising radiotracer for imaging CB2 in rodents. It might serve as a tool for the investigation of CB2 receptor expression levels in healthy tissues and different neuroinflammatory disorders in humans.

NOVEL PYRIDINE DERIVATIVES

The invention relates to a compound of formula (I) wherein R1 to R3 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.