4,8-di(4-trifluoromethylphenyl)benzo[1,2-b:4,5-b']dithiophene

Base Information

• Chemical Name: 4,8-di(4-trifluoromethylphenyl)benzo[1,2-b:4,5-b']dithiophene
• CAS No.: 1620482-30-5
• Molecular Formula: C₂₄H₁₂F₆S₂
• Molecular Weight: 478.482
• Mol file: 1620482-30-5.mol

Synonyms:4,8-di(4-trifluoromethylphenyl)benzo[1,2-b:4,5-b']dithiophene

Chemical Property of 4,8-di(4-trifluoromethylphenyl)benzo[1,2-b:4,5-b']dithiophene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,8-di(4-trifluoromethylphenyl)benzo[1,2-b:4,5-b']dithiophene

There total 3 articles about 4,8-di(4-trifluoromethylphenyl)benzo[1,2-b:4,5-b']dithiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

benzo[1,2-b:4,5-b']dithiophene-4,8-diyl bis(trifluoromethanesulfonate) (1620482-22-5) + 4-trifluoromethylphenylboronic acid (128796-39-4) → 4,8-di(4-trifluoromethylphenyl)benzo[1,2-b:4,5-b']dithiophene (1620482-30-5)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In tetrahydrofuran; water; at 85 ℃; for 16h;

DOI:10.1039/c4ta01226g

Reference yield:

4,8-dihydroxybenzo[1,2-b:4,5-b']dithiophene (1357156-35-4) → 4,8-di(4-trifluoromethylphenyl)benzo[1,2-b:4,5-b']dithiophene (1620482-30-5)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 12 h / 0 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / tetrahydrofuran; water / 16 h / 85 °C

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In tetrahydrofuran; dichloromethane; water; 2: |Suzuki Coupling;

DOI:10.1039/c4ta01226g

Reference yield:

4,8-dihydrobenzo[1,2-b:4,5-b']dithiophene-4,8-dione (32281-36-0) → 4,8-di(4-trifluoromethylphenyl)benzo[1,2-b:4,5-b']dithiophene (1620482-30-5)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium tetrahydroborate / ethanol / 12 h / 85 °C / Cooling with ice

2: pyridine / dichloromethane / 12 h / 0 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / tetrahydrofuran; water / 16 h / 85 °C

With pyridine; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In tetrahydrofuran; ethanol; dichloromethane; water; 3: |Suzuki Coupling;

DOI:10.1039/c4ta01226g

upstream raw materials:

4,8-dihydrobenzo[1,2-b:4,5-b']dithiophene-4,8-dione

benzo[1,2-b:4,5-b']dithiophene-4,8-diyl bis(trifluoromethanesulfonate)

4-trifluoromethylphenylboronic acid

4,8-dihydroxybenzo[1,2-b:4,5-b']dithiophene